| Stardust Telepath | October 9, 2023 | — | 12 |
| Stars Align | October 10, 2019 | — | 12 |
| Starship Girl Yamamoto Yohko | April 4, 1999 | TV Osaka | 26 |
| Starship Operators | January 5, 2005 | TV Tokyo | 13 |
| Starzinger | April 2, 1978 | Fuji Television | — |
| Steam Detectives | October 7, 1998 | — | 26 |
| Steel Angel Kurumi | October 5, 1999 | — | 24 |
| Steel Angel Kurumi 2 | April 12, 2001 | — | 12 |
| Steel Jeeg | October 5, 1975 | TV Asahi | 46 |
| Steins;Gate | April 6, 2011 | — | 26 |
| Steins;Gate 0 | April 12, 2018 | — | 23 |
| Stella Women’s Academy, High School Division Class C³ | July 4, 2013 | — | 13 |
| Stellvia | April 2, 2003 | — | 26 |
| Stitch! | October 8, 2008 | — | 88 |
| Stop!! Hibari-kun! | May 20, 1983 | — | 35 |
| Story of the Alps: My Annette | January 9, 1983 | — | 48 |
| Straight Title Robot Anime | February 6, 2013 | — | — |
| Strain: Strategic Armored Infantry | November 2, 2006 | — | 13 |
| Strange Dawn | July 11, 2000 | WOWOW | 13 |
| Strange+ | January 9, 2014 | — | 24 |
| Stratos 4 | January 5, 2003 | — | — |
| Strawberry 100% | April 5, 2005 | TV Asahi | 12 |
| Strawberry Marshmallow | July 14, 2005 | — | 12 |
| Strawberry Panic! | April 3, 2006 | — | 26 |
| Street Fighter II V | April 10, 1995 | — | 29 |
| Strike the Blood | October 4, 2013 | — | 24 |
| Strike Witches | July 3, 2008 | — | 12 |
| Strike Witches 2 | July 7, 2010 | — | 12 |
| Strike Witches: 501st Joint Fighter Wing Take Off! | April 9, 2019 | — | 12 |
| Strike Witches: Road to Berlin | — | — | — |
| Student Council's Discretion | October 2, 2009 | Nippon Television | 12 |
| Studio Apartment, Good Lighting, Angel Included | April 6, 2024 | — | 12 |
| Studio Cabana | 2027 | — | — |
| Subete ga F ni Naru | October 8, 2015 | Fuji Television | 11 |
| Submarine Super 99 | May 8, 2003 | AT-X | 13 |
| Sue Cat | April 6, 1980 | — | 40 |
| Sugar Apple Fairy Tale | January 6, 2023 | — | 24 |
| Sugar Soldier | January 14, 2014 | — | 3 |
| Sugar Sugar Rune | July 2, 2005 | TV Tokyo | 51 |
| Sugarbunnies | April 3, 2007 | — | 27 |
| Sugarbunnies: Chocolat! | April 9, 2008 | — | 27 |
| Sugarbunnies: Fleur | April 7, 2009 | — | 26 |
| Suicide Squad Isekai | June 27, 2024 | HBO Max | 10 |
| Suikoden | October 3, 2026 | — | — |
| Suite PreCure | February 6, 2011 | TV Asahi | 48 |
| Sukisho | January 7, 2005 | — | 13 |
| Summer Pockets | April 7, 2025 | — | 26 |
| Summer Time Rendering | April 14, 2022 | — | 25 |
| Summoned to Another World... Again? | April 9, 2023 | — | 12 |
| Sunday Without God | July 6, 2013 | — | 12 |
| Sunset on Third Street | October 12, 1990 | — | 27 |
| Super Bikkuriman | May 17, 1992 | — | 44 |
| Super Cub | April 7, 2021 | — | 12 |
| Super Dimension Cavalry Southern Cross | April 15, 1984 | — | 23 |
| Super Dimension Century Orguss | July 3, 1983 | — | 35 |
| Super Dimension Fortress Macross | October 3, 1982 | — | 36 |
| Super Doll Licca-chan | October 6, 1998 | TV Tokyo | 52 |
| Super Express Hikarian | April 2, 1997 | — | 156 |
| Super Gals! Kotobuki Ran | April 1, 2001 | TV Tokyo | 52 |
| Super HxEros | July 4, 2020 | — | 12 |