| Uchi no Sanshimai | April 4, 2008 | TV Tokyo | 141 |
| Uchitama?! Have you seen my Tama? | January 10, 2020 | — | — |
| Uchurei! | — | — | — |
| Uchū Majin Daikengo | July 27, 1978 | — | — |
| Uchū Nanchara Kotetsu-kun | April 7, 2021 | NHK Educational TV | — |
| Uchūsen Sagittarius | January 10, 1986 | TV Asahi | 77 |
| UFO Baby | March 28, 2000 | NHK Satellite 2 Television | 78 |
| UFO Ultramaiden Valkyrie | July 4, 2002 | — | 24 |
| UFO Warrior Dai Apolon | April 6, 1976 | TBS Television | 47 |
| Uglymug, Epicfighter | July 6, 2025 | — | 12 |
| Ukkari Pénélope | November 20, 2006 | NHK Educational TV | 52 |
| Ultimate Girls | January 10, 2005 | — | 12 |
| Ultimate Otaku Teacher | April 4, 2015 | Yomiuri Telecasting Corporation | 24 |
| Ultra B | April 4, 1987 | — | 118 |
| Ultra Maniac | May 20, 2003 | — | 26 |
| Ultraviolet: Code 044 | July 1, 2008 | — | — |
| Ulysses 31 | October 10, 1981 | France 3 | 26 |
| Ulysses: Jeanne d'Arc and the Alchemist Knight | October 7, 2018 | — | 12 |
| Umamusume: Cinderella Gray | April 6, 2025 | — | — |
| Umamusume: Pretty Derby | April 2, 2018 | — | — |
| Umayon | July 7, 2020 | — | 12 |
| Umeboshi Denka | April 1, 1969 | TBS Television | 26 |
| Umi Monogatari | June 24, 2009 | — | 12 |
| Umi no Minwa no Machi | December 2023 | — | 25 |
| Umineko When They Cry | July 2, 2009 | Chiba Television Broadcasting | 26 |
| Un-Go | October 13, 2011 | — | 11 |
| Unbreakable Machine-Doll | October 7, 2013 | — | 12 |
| Uncle From Another World | July 6, 2022 | — | — |
| Uncle's Obsession with Cute Things | October 4, 2026 | — | — |
| Undead Girl Murder Farce | July 6, 2023 | — | 13 |
| Undead Unluck | October 7, 2023 | — | 24 |
| Undefeated Bahamut Chronicle | January 11, 2016 | — | 12 |
| Under Ninja | October 6, 2023 | — | 12 |
| Unexpectedly Naughty Fukami | April 7, 2025 | — | — |
| Uninhabited Planet Survive! | October 16, 2003 | NHK Educational TV | 52 |
| UniteUp! | January 7, 2023 | — | — |
| Unlimited Fafnir | January 8, 2015 | — | 12 |
| Unlimited Psychic Squad | January 7, 2013 | TV Tokyo | 12 |
| Unnamed Memory | April 9, 2024 | — | — |
| UQ Holder! | October 2, 2017 | — | 12 |
| Urahara | October 4, 2017 | — | 12 |
| Urara Meirocho | January 5, 2017 | — | 12 |
| Urawa no Usagi-chan | April 9, 2015 | — | 12 |
| Urikupen Kyūjotai | September 30, 1974 | Fuji Television | 132 |
| Urusei Yatsura | October 14, 1981 | Fuji Television | 195 |
| Urusei Yatsura | October 14, 2022 | Fuji Television | — |
| Usakame | April 11, 2016 | Tokyo MX | 12 |
| Ushio & Tora | July 3, 2015 | — | 39 |
| Uta Kata | October 3, 2004 | — | 12 |
| Uta no Prince-sama | July 3, 2011 | — | 52 |
| Utahime Dream | — | — | — |
| Utawarerumono | April 3, 2006 | — | 26 |
| Uzaki-chan Wants to Hang Out! | July 10, 2020 | — | 25 |
| Uzumaki | September 29, 2024 | — | 4 |
| Val × Love | October 5, 2019 | — | 12 |
| Valkyria Chronicles | April 4, 2009 | — | 26 |
| Valkyrie Drive: Mermaid | October 10, 2015 | — | 12 |
| Valvrave the Liberator | April 12, 2013 | — | 24 |
| Vampire Dormitory | April 7, 2024 | — | 12 |
| Vampire Holmes | — | — | — |