| Space Ace | May 8, 1965 | Fuji Television | 52 |
| Space Battleship Tiramisu | April 3, 2018 | — | 26 |
| Space Battleship Yamato | October 6, 1974 | Yomiuri Telecasting Corporation | 26 |
| Space Battleship Yamato 2202: Warriors of Love | October 6, 2018 | — | — |
| Space Battleship Yamato II | October 14, 1978 | Yomiuri Telecasting Corporation | 26 |
| Space Battleship Yamato III | October 11, 1980 | Yomiuri Telecasting Corporation | 25 |
| Space Boy Soran | May 4, 1965 | — | 96 |
| Space Brothers | March 31, 2012 | — | 99 |
| Space Carrier Blue Noah | October 13, 1979 | — | 24 |
| Space Cobra | October 7, 1982 | — | 31 |
| Space Dandy | January 4, 2014 | — | 26 |
| Space Emperor God Sigma | March 19, 1980 | — | 50 |
| Space Patrol Luluco | April 1, 2016 | Tokyo MX, AT-X, Nippon BS Broadcasting | 13 |
| Space Pirate Captain Harlock | March 14, 1978 | TV Asahi | 42 |
| Space Pirate Mito | January 5, 1999 | — | — |
| Space Runaway Ideon | May 8, 1980 | — | 39 |
| Space Symphony Maetel | August 5, 2004 | — | 15 |
| Space Warrior Baldios | June 30, 1980 | TV Tokyo | 31 |
| Sparks of Tomorrow | July 5, 2026 | — | 13 |
| Sparrow's Hotel | April 9, 2013 | — | 12 |
| Special A | April 6, 2008 | Chiba Television Broadcasting | 24 |
| Special Armored Battalion Dorvack | October 7, 1983 | — | 36 |
| Special Crime Investigation Unit Special 7 | October 6, 2019 | — | 12 |
| Special Kid Factory | — | — | — |
| Speed Grapher | April 7, 2005 | TV Asahi | 24 |
| Speed Racer | April 2, 1967 | Fuji Television | 52 |
| Spice and Wolf | January 2008 | — | 26 |
| Spice and Wolf: Merchant Meets the Wise Wolf | April 2, 2024 | — | 25 |
| Spider Riders | March 25, 2006 | Kids' WB | 52 |
| Spiral: The Bonds of Reasoning | October 1, 2002 | TV Tokyo | 25 |
| Spirit Circle | — | — | — |
| Spirit of Wonder: Shōnen Kagaku Club | January 25, 2001 | — | 2 |
| Spirit Warrior | — | — | — |
| Spocon! | September 26, 2014 | — | 2 |
| Spriggan | June 18, 2022 | Netflix | 6 |
| Spy Classroom | January 5, 2023 | — | 12 |
| Spy × Family | April 9, 2022 | — | 50 |
| Squid Girl | October 5, 2010 | TV Tokyo | 24 |
| SSS-Class Revival Hunter | January 2027 | — | — |
| SSSS.Dynazenon | April 2, 2021 | — | 12 |
| SSSS.Gridman | October 7, 2018 | — | 12 |
| St. Luminous Mission High School | October 5, 1998 | — | 13 |
| St. Michaela Gakuen Hyōryūki | June 22, 1990 | — | 2 |
| St. Michaela Gakuen Hyōryūki II | October 21, 1994 | — | 2 |
| STAND MY HEROES PIECE OF TRUTH | — | — | — |
| Stand My Heroes: Piece of Truth | October 7, 2019 | — | 12 |
| Star Blazers 2199 | April 7, 2013 | MBS | — |
| Star Detective Precure! | February 1, 2026 | — | — |
| Star Driver | October 3, 2010 | — | 25 |
| Star Ocean EX | April 3, 2001 | — | 26 |
| Star of the Giants | March 30, 1968 | — | — |
| Star Twinkle Precure | February 3, 2019 | — | 49 |
| Star Wars: Visions | September 22, 2021 | Disney+ | 18 |
| Star-Myu | October 5, 2015 | — | 36 |
| Stardust Telepath | October 9, 2023 | — | 12 |
| Stars Align | October 10, 2019 | — | 12 |
| Starship Girl Yamamoto Yohko | April 4, 1999 | TV Osaka | 26 |
| Starship Girl Yamamoto Yohko | March 6, 1996 | — | 3 |
| Starship Girl Yamamoto Yohko II | August 6, 1997 | — | 3 |
| Starship Operators | January 5, 2005 | TV Tokyo | 13 |