| Seiren | January 5, 2017 | — | 12 |
| Seitokai Yakuindomo | July 4, 2010 | — | 26 |
| Seiyu's Life! | July 7, 2015 | — | 13 |
| Seiyuu Sentai Voicetorm 7 | October 6, 2013 | — | 11 |
| Sekirei | July 2, 2008 | — | 12 |
| Sekirei: Pure Engagement | July 4, 2010 | — | 13 |
| Sekiro: No Defeat | — | — | — |
| Sekkō Boys | January 8, 2016 | Nippon BS Broadcasting | — |
| Selection Project | October 1, 2021 | — | — |
| Selector Infected WIXOSS | April 4, 2014 | — | 12 |
| Selector spread WIXOSS | — | — | 12 |
| Sengoku Basara: End of Judgement | July 6, 2014 | — | 12 |
| Sengoku Basara: Samurai Kings | April 2, 2009 | — | 26 |
| Sengoku Collection | April 6, 2012 | — | — |
| Sengoku Night Blood | October 3, 2017 | — | 12 |
| Sengoku Paradise | October 4, 2011 | — | — |
| Sengoku Youko | January 11, 2024 | — | 35 |
| Sengokuchojugiga | October 9, 2016 | — | — |
| Sennin Buraku | September 4, 1963 | — | 23 |
| Senpai Is an Otokonoko | July 5, 2024 | — | 12 |
| Senran Kagura | January 6, 2013 | — | 12 |
| Senran Kagura Shinovi Master | October 13, 2018 | — | 12 |
| Senren Banka | 2027 | — | — |
| Senryu Girl | April 6, 2019 | — | 12 |
| Sensual Phrase | April 20, 1999 | TV Tokyo | 44 |
| Sentenced to Be a Hero | January 3, 2026 | — | 12 |
| Sentimental Journey | April 8, 1998 | — | 12 |
| Senyu | January 9, 2013 | — | 26 |
| Seraph of the End | April 4, 2015 | — | 24 |
| Seraphim Call | October 6, 1999 | — | 12 |
| Serendipity the Pink Dragon | July 1, 1983 | Nippon Television | 26 |
| Serial Experiments Lain | July 6, 1998 | TV Tokyo | 13 |
| Servamp | July 5, 2016 | — | — |
| Servant × Service | July 5, 2013 | — | 13 |
| Seton Academy: Join the Pack! | January 7, 2020 | — | — |
| Seton Dōbutsuki | October 14, 1989 | — | 45 |
| Seven Mortal Sins | April 14, 2017 | — | 12 |
| Seven of Seven | January 10, 2002 | TV Tokyo | 25 |
| Seven Senses of the Re'Union | July 6, 2018 | — | 12 |
| Sexy Commando Gaiden | January 5, 1998 | TBS Television | — |
| Sgt. Frog | April 3, 2004 | TV Tokyo | 358 |
| Sgt. Frog☆ | October 3, 2026 | — | — |
| Shabake | October 3, 2025 | — | 13 |
| Shachibato! President, It's Time for Battle! | April 5, 2020 | — | 12 |
| Shadow Skill: Eigi | July 3, 1998 | — | — |
| Shadow Star | July 7, 2003 | — | 13 |
| Shadows House | April 11, 2021 | — | 25 |
| Shadowverse | April 7, 2020 | — | — |
| Shakugan no Shana | October 6, 2005 | — | 72 |
| Shaman King | July 4, 2001 | TV Tokyo | 64 |
| Shaman King | April 1, 2021 | — | 52 |
| Shaman King: Flowers | January 10, 2024 | TX Network | 13 |
| Shangri-La | April 6, 2009 | Chiba Television Broadcasting | 24 |
| Shangri-La Frontier | October 1, 2023 | — | 50 |
| Shattered Angels | January 5, 2007 | — | 12 |
| She and Her Cat: Everything Flows | March 4, 2016 | — | 4 |
| She Professed Herself Pupil of the Wise Man | January 12, 2022 | — | 12 |
| Shenmue: The Animation | February 6, 2022 | Cartoon Network | 13 |
| Sherlock Hound | November 6, 1984 | TV Asahi | 26 |
| Shiba Inu Rooms | 2027 | — | — |