| E. C. Segar | screenwriter, writer, comics artist, comics writer | 3 |
| E. Nelson Bridwell | editor | 5 |
| Earl Derr Biggers | writer, playwright, journalist, novelist, crime fiction writer | 1 |
| Eckart Fingberg | screenwriter, illustrator, creator, film director, director, picture book writer, draftsperson | 1 |
| Ed Boon | screenwriter, game programmer, director, programmer, video game designer, video game developer | 1 |
| Ed Graham | drummer, musician | 1 |
| Eddie Murphy | screenwriter, singer, comedian, voice actor, film director, film producer, television actor, film actor | 1 |
| Eduard Kyrych | screenwriter, animator, painter | 1 |
| Eduard Uspensky | screenwriter, writer, poet, engineer, playwright, television presenter, film producer, children's writer | 1 |
| Edward Neumeier | screenwriter, actor, executive producer, film producer, director, film screenwriter | 1 |
| Eiichiro Oda | screenwriter, mangaka, comics artist, executive producer, caricaturist, comics creator | 2 |
| Elanna Allen | animator, illustrator, children's writer | 1 |
| Eli Roth | screenwriter, actor, animator, film director, film producer, director, film actor | 2 |
| Elisabeth Beresford | writer, journalist | 1 |
| Elisabetta Gnone | writer, author, comics artist, cartoonist, journalist, comics creator | 1 |
| Elise Allen | screenwriter, television producer, novelist | 1 |
| Elliot M. Bour | actor, film director, director, character animator | 1 |
| Else Holmelund Minarik | children's writer | 1 |
| Elyne Mitchell | writer, children's writer | 1 |
| Emily Kapnek | screenwriter, actor, television producer, songwriter, showrunner, voice actor, film producer | 1 |
| Emily Spivey | screenwriter, actor, television producer, voice actor | 1 |
| Enid Blyton | screenwriter, writer, teacher, poet, school teacher, children's writer, novelist | 2 |
| Er Gen | writer, fantasy author, novelist, online writer | 3 |
| Eric Branscum | screenwriter | 1 |
| Eric Darnell | screenwriter, actor, animator, television producer, film director, film producer, director, film screenwriter | 1 |
| Eric Fogel | screenwriter, animator, television producer, television director, voice actor, film director | 3 |
| Eric Kaplan | screenwriter, television producer, film producer | 1 |
| Eric Robles | screenwriter, animator | 1 |
| Erik Richter | screenwriter | 1 |
| Ethan Nicolle | illustrator | 1 |
| Eva Almos | screenwriter, actor | 1 |
| Everett Downing Jr. | screenwriter, animator, animation director, television director, voice actor, film director, storyboard artist | 1 |
| Everett Peck | animator, comics artist | 2 |
| Ezra Koenig | teacher, singer, musician, songwriter, guitarist | 1 |