| Salavat Shayhinurov | animator, news presenter, television presenter, production designer, designer | 1 |
| Sam Register | businessperson, television producer, film producer | 2 |
| Sandro Corsaro | screenwriter, animator, television producer | 1 |
| Sandy Frank | television producer | 1 |
| Sanjiu Yinyu | writer, author, book writer, fantasy author, novelist, online writer | 1 |
| Satoshi Kon | screenwriter, mangaka, animator, comics artist, film director, director | 1 |
| Satoshi Tajiri | screenwriter, computer scientist, entrepreneur, video game developer, video game director | 1 |
| Savage Steve Holland | screenwriter, animator, television producer, casting director, voice actor, film director, director | 2 |
| Savin Yeatman-Eiffel | screenwriter, writer, film director | 1 |
| Scott Adams | writer, engineer, comics artist, banker, executive, caricaturist, programmer, blogger | 1 |
| Scott Fellows | screenwriter, television producer | 1 |
| Scott Gimple | screenwriter, television producer, showrunner, comics writer | 1 |
| SEN | comics artist, cartoonist, editorial cartoonist, caricaturist | 1 |
| Serge Danot | screenwriter, animator, film director, director | 1 |
| Sergey Merinov | animator, film director | 1 |
| Seth Green | screenwriter, actor, writer, television producer, film director, film producer, director, television writer | 3 |
| Seth MacFarlane | screenwriter, actor, composer, television producer, musician, lyricist, film producer, director | 4 |
| Shannon Tindle | screenwriter, animator, film director | 1 |
| Sherwood Schwartz | screenwriter, television producer, documentary participant | 2 |
| Shigeru Miyamoto | screenwriter, director, video game producer, film producer, game designer, designer, video artist, video game designer | 2 |
| Shinji Aramaki | film director, director, mechanical designer | 1 |
| Shiren Wen | businessperson, novelist | 1 |
| Shirō Jinbo | manga gensakusha, novelist | 1 |
| Shuyu Li | screenwriter, animator, animation director, character designer, key animator, storyboard artist | 1 |
| Shō Aikawa | screenwriter | 2 |
| Shōji Kawamori | screenwriter, film director, mechanical designer | 4 |
| Simon Kinberg | screenwriter, actor, executive producer, film director, film producer | 1 |
| Simon Tofield | writer, illustrator, film director, director, film editor | 1 |
| Sofia Alexander | actor, animator, television producer | 1 |
| Sonia Holleyman | — | 1 |
| Sono Patel | screenwriter, television producer | 1 |
| Stan Lee | executive producer, editor, journalist, voice actor, film actor, comics writer, science fiction writer, comics editor | 23 |
| Stanley Moore | director, producer | 1 |
| Stephen Colbert | screenwriter, actor, writer, comedian, television producer, television presenter | 1 |
| Stephen Hillenburg | screenwriter, animator, painter, cartoonist, university teacher, voice actor, film director, film producer | 1 |
| Stephen P. Neary | animator, television producer, voice actor | 1 |
| Stephen Sommers | screenwriter, actor, writer, film director, film producer, director, film actor, manufacturer | 1 |
| Steve Binder | television producer, film director, film producer | 1 |
| Steve Borst | screenwriter, television producer, television director | 1 |
| Steve Dildarian | screenwriter, television producer, television director, voice actor | 2 |
| Steve Ditko | screenwriter, illustrator, comics artist, draftsperson | 2 |
| Steve Gerber | screenwriter, comics artist, cartoonist, journalist | 1 |
| Steve Hely | screenwriter, voice actor | 1 |
| Steve Marmel | screenwriter, actor, comedian, television producer, songwriter, lyricist | 1 |
| Steve Oedekerk | screenwriter, writer, executive producer, film director, film producer, director, film actor, producer | 3 |
| Steve Purcell | screenwriter, animator, comics artist, painter, cartoonist, voice actor, film director, director | 1 |
| Steven E. de Souza | screenwriter, actor, film director, film producer | 1 |
| Steven Lisberger | screenwriter, writer, animator, film director, film producer, director | 1 |
| Steven Spielberg | actor, writer, television producer, film director, film producer, director, film editor, film screenwriter | 2 |
| Sue Rose | screenwriter, animator, television producer, voice actor | 1 |
| Suhoon Kim | chief executive officer, executive producer, creator, film director | 2 |
| Susan Meddaugh | author, illustrator | 1 |
| Sylvia Anderson | screenwriter, costume designer, talent agent, film director, film producer, director, dub actor, autobiographer | 1 |