| Ulysses: Jeanne d'Arc and the Alchemist Knight | October 7, 2018 | — | 12 |
| Umamusume: Cinderella Gray | April 6, 2025 | — | — |
| Umamusume: Pretty Derby | April 2, 2018 | — | — |
| Umayon | July 7, 2020 | — | 12 |
| Umayuru: Full Gate! | September 27, 2026 | — | — |
| Umeboshi Denka | April 1, 1969 | TBS Television | 26 |
| Umi Monogatari | June 24, 2009 | — | 12 |
| Umi no Minwa no Machi | December 2023 | — | 25 |
| Umineko When They Cry | July 2, 2009 | Chiba Television Broadcasting | 26 |
| Un-Go | October 13, 2011 | — | 11 |
| Unbreakable Machine-Doll | October 7, 2013 | — | 12 |
| Unbreakable Machine-Doll | December 25, 2013 | — | 6 |
| Uncharted: Eye of Indra | — | — | 4 |
| Uncle From Another World | July 6, 2022 | — | — |
| Uncle Grandpa | September 2, 2013 | Cartoon Network | 156 |
| Uncle's Obsession with Cute Things | October 4, 2026 | — | — |
| Undead Girl Murder Farce | July 6, 2023 | — | 13 |
| Undead Unluck | October 7, 2023 | — | 24 |
| Undefeated Bahamut Chronicle | January 11, 2016 | — | 12 |
| Under Ninja | October 6, 2023 | — | 12 |
| Underdog | October 3, 1964 | NBC, CBS | 124 |
| Undergrads | April 1, 2001 | Adult Swim, Cartoon Network, MTV2 | 13 |
| Undone | September 13, 2019 | Amazon Prime Video | 16 |
| Unexpectedly Naughty Fukami | April 7, 2025 | — | — |
| Unicorn Academy | November 2, 2023 | — | — |
| Unikitty! | October 27, 2017 | Cartoon Network | 104 |
| Uniminipet | June 15, 2001 | SBS TV | 26 |
| Uninhabited Planet Survive! | October 16, 2003 | NHK Educational TV | 52 |
| UniteUp! | January 7, 2023 | — | — |
| Universo Z | — | — | — |
| Unkai no Meikyū Zeguy | — | — | — |
| Unlimited Fafnir | January 8, 2015 | — | 12 |
| Unlimited Psychic Squad | January 7, 2013 | TV Tokyo | 12 |
| Unnamed Memory | April 9, 2024 | — | — |
| Unsupervised | January 19, 2012 | FX | 13 |
| Untalkative Bunny | April 15, 2001 | Cartoon Network | 65 |
| Upin & Ipin | September 14, 2007 | Hungama TV, Disney Channel Asia, TV9, 8TV | 270 |
| Upotte!! | — | — | — |
| UQ Holder! | October 2, 2017 | — | 12 |
| Urahara | October 4, 2017 | — | 12 |
| Urara Meirocho | January 5, 2017 | — | 12 |
| Urawa no Usagi-chan | April 9, 2015 | — | 12 |
| Urban legends Story | April 19, 2026 | Bilibili, YouTube TV | 16 |
| Urikupen Kyūjotai | September 30, 1974 | Fuji Television | 132 |
| Urusei Yatsura | October 14, 1981 | Fuji Television | 195 |
| Urusei Yatsura | — | — | — |
| Urusei Yatsura | October 14, 2022 | Fuji Television | — |
| Usakame | April 11, 2016 | Tokyo MX | 12 |
| Usavich | 2006 | MTV | 78 |
| Useful tips from Professor Chaynikov | — | — | 6 |
| Ushio & Tora | July 3, 2015 | — | 39 |
| Ushio & Tora | September 11, 1992 | — | 11 |
| Uta Kata | October 3, 2004 | — | 12 |
| Uta no Prince-sama | July 3, 2011 | — | 52 |
| Utahime Dream | — | — | — |
| Utawarerumono | April 3, 2006 | — | 26 |
| Uzaki-chan Wants to Hang Out! | July 10, 2020 | — | 25 |
| Uzumaki | September 29, 2024 | — | 4 |
| Val × Love | October 5, 2019 | — | 12 |
| Valkyria Chronicles | April 4, 2009 | — | 26 |