| Sabrina the Teenage Witch | September 14, 1970 | CBS | 31 |
| Sabrina's Secret Life | November 10, 2003 | Broadcast syndication | 26 |
| Sabrina: Secrets of a Teenage Witch | October 12, 2013 | Discovery Family | 26 |
| Sabrina: The Animated Series | September 6, 1999 | American Broadcasting Company, UPN | 65 |
| Sabu to Ichi Torimono Hikae | October 3, 1968 | — | 52 |
| Sacred Seven | July 3, 2011 | — | 12 |
| Sacrificial Princess and the King of Beasts | April 20, 2023 | — | 24 |
| Sadamitsu the Destroyer | January 17, 2001 | WOWOW | 10 |
| Sadie Sparks | April 20, 2019 | Disney Channel | 52 |
| Saekano | January 9, 2015 | — | 24 |
| Sago Mini Friends | September 16, 2022 | — | — |
| Sagrada Reset | April 5, 2017 | — | 24 |
| Sagwa, the Chinese Siamese Cat | September 3, 2001 | Treehouse TV, PBS Kids | 40 |
| Saikano | July 2, 2002 | — | 13 |
| Saikano: Another Love Song | August 5, 2005 | — | 2 |
| Saikyō Kamizmode! | October 9, 2020 | — | 26 |
| Sailor Moon | March 7, 1992 | TV Asahi | 200 |
| Sailor Moon | — | — | 159 |
| Sailor Moon Crystal | July 5, 2014 | — | 39 |
| Sailor Victory | — | — | — |
| Saint Beast | — | — | — |
| Saint Beast: Ikusen no Hiru to Yoru-hen | December 17, 2005 | — | 2 |
| Saint Beast: Kōin Jojishi Tenshi Tan | April 3, 2007 | — | 13 |
| Saint Beast: Seijū Kōrin-hen | May 9, 2003 | — | 6 |
| Saint Cecilia and Pastor Lawrence | July 13, 2023 | — | 12 |
| Saint October | January 4, 2007 | — | 26 |
| Saint Seiya | October 11, 1986 | — | 114 |
| Saint Seiya Omega | April 1, 2012 | — | — |
| Saint Seiya: Saintia Shō | December 10, 2018 | — | 10 |
| Saint Seiya: Soul of Gold | April 11, 2015 | — | — |
| Saint Seiya: The Hades | — | — | 31 |
| Saint Seiya: The Hades Chapter - Inferno | December 17, 2005 | — | 12 |
| Saint Tail | October 12, 1995 | TV Asahi | 43 |
| Saint Young Men | December 3, 2012 | — | — |
| Saiyuki | April 4, 2000 | — | 50 |
| Saiyuki Gaiden | March 25, 2011 | — | 4 |
| Saiyuki Premium | April 23, 1999 | — | 2 |
| Saiyuki Reload | October 2, 2003 | TV Tokyo | 51 |
| Saiyuki Reload Blast | July 5, 2017 | — | 12 |
| Saiyuki Reload Gunlock | April 1, 2004 | — | 26 |
| Saiyuki Reload: Burial | April 27, 2007 | — | 3 |
| Saiyuki Reload: Zeroin | January 6, 2022 | — | 13 |
| Sakamoto Days | January 11, 2025 | — | 22 |
| Saki | April 6, 2009 | TV Tokyo | 25 |
| Saki Achiga-hen episode of Side-A | April 9, 2012 | — | 16 |
| Saki: The Nationals | January 5, 2014 | — | 13 |
| Sakigake!! Otokojuku | February 25, 1988 | Fuji Television | 34 |
| Sakon, the Ventriloquist | October 8, 1999 | WOWOW | 26 |
| Sakugan | October 7, 2021 | — | 12 |
| Sakuna: Of Rice and Ruin | July 6, 2024 | — | 13 |
| Sakura Diaries | May 21, 1997 | — | 12 |
| Sakura Momoko Gekijō Coji-Coji | October 4, 1997 | — | 100 |
| Sakura Quest | April 5, 2017 | — | 25 |
| Sakura Trick | January 9, 2014 | TBS Television | 12 |
| Sakura Wars | April 8, 2000 | TBS Television | 25 |
| Sakura Wars the Animation | April 3, 2020 | Tokyo MX, Nippon BS Broadcasting | 12 |
| Sakura Wars: The Gorgeous Blooming Cherry Blossoms | December 18, 1997 | — | — |
| Sakura Wars: The Radiant Gorgeous Blooming Cherry Blossoms | December 18, 1999 | — | 6 |
| Salad Jū Yūshi Tomatoman | April 3, 1992 | — | 50 |
| Saladin: The Animated Series | September 1, 2010 | Astro Ria | 13 |