| Scary Scooby Funnies | October 20, 1984 | American Broadcasting Company | — |
| Scavengers Reign | October 19, 2023 | HBO Max | 12 |
| Scenes From Awajima | April 10, 2026 | — | 12 |
| School Babysitters | January 7, 2018 | — | 12 |
| School Days | July 3, 2007 | — | 12 |
| School for Vampires | August 26, 2006 | Das Erste | 104 |
| School Rumble | October 5, 2004 | TV Tokyo | 56 |
| School-Live! | July 9, 2015 | — | 12 |
| Schoolgirl Strikers | — | — | — |
| Schoolhouse Rock! | January 6, 1973 | American Broadcasting Company | 64 |
| Schwarzesmarken | January 10, 2016 | — | 12 |
| Sci-Fi Harry | October 5, 2000 | — | 20 |
| Science Fell in Love, So I Tried to Prove It | January 11, 2020 | — | 24 |
| Science Ninja Team Gatchaman | October 1, 1972 | Fuji Television | 105 |
| Scissor Seven | April 25, 2018 | — | — |
| Scooby's All-Star Laff-A-Lympics | September 10, 1977 | American Broadcasting Company | 24 |
| Scooby's Mystery Funhouse | September 7, 1985 | American Broadcasting Company | 21 |
| Scooby-Doo and Guess Who? | June 27, 2019 | Cartoon Network | 26 |
| Scooby-Doo and Scrappy-Doo | September 22, 1979 | American Broadcasting Company | 16 |
| Scooby-Doo and Scrappy-Doo | November 8, 1980 | American Broadcasting Company | 33 |
| Scooby-Doo! Mystery Incorporated | April 5, 2010 | Cartoon Network | 52 |
| Scooby-Doo, Where Are You! | September 13, 1969 | CBS | 25 |
| Scooped Up by an S-Rank Adventurer! | July 11, 2025 | — | 12 |
| Scorching Ping Pong Girls | October 3, 2016 | — | 12 |
| Scott Pilgrim Takes Off | November 17, 2023 | Netflix | 8 |
| Scrapped Princess | April 8, 2003 | — | 24 |
| Screechers Wild! | — | Nickelodeon, Carousel | — |
| Scruff | November 1, 2000 | 33 | 104 |
| Scruffy | — | — | 3 |
| Scum of the Brave | January 11, 2026 | — | 24 |
| Scum's Wish | January 12, 2017 | — | 12 |
| Scumbag System | — | Tencent Video | — |
| SD Gundam Sangokuden Brave Battle Warriors | April 3, 2010 | — | 51 |
| SD Gundam World Heroes | April 8, 2021 | — | — |
| SD Gundam World Sangoku Soketsuden | July 26, 2019 | — | 10 |
| Sea Dogs: Adventures on the Seven Seas | — | — | — |
| Sea Princesses | 2007 | Australian Broadcasting Corporation, Discovery Familia, Discovery Kids | 104 |
| Seabert | October 3, 1985 | Antenne 2 | 52 |
| Sealab 2020 | September 9, 1972 | NBC | 13 |
| Sealab 2021 | December 21, 2000 | Adult Swim | 52 |
| Sealook | — | KBS 1TV | 20 |
| Seaside Hotel | — | — | 26 |
| Season Elves | — | Kaku Children's Television | 52 |
| Secret Jouju: Bijou of Star | — | JEI TV | — |
| Secret Jouju: Guardians of Star | — | Tooniverse | 26 |
| Secret Jouju: Guardians of Star | — | JEI TV | 60 |
| Secret Level | — | Amazon Prime Video | 15 |
| Secret Millionaires Club | October 23, 2011 | Hub Network | 26 |
| Secret Mountain Fort Awesome | August 1, 2011 | Cartoon Network | 26 |
| Secret of Cerulean Sand | January 5, 2002 | WOWOW | 26 |
| Secret of the Cave | — | MBC 2 | 30 |
| Secret Squirrel | 1965 | NBC, Cartoon Network | 39 |
| Secrets of the Rivers | — | — | — |
| Secrets of the Silent Witch | July 5, 2025 | — | 13 |
| Sectaurs | — | — | — |
| See You Tomorrow at the Food Court | July 7, 2025 | — | 6 |
| Seigi wo Ai Suru Mono – Gekkō Kamen | January 10, 1972 | — | 39 |
| Seirei Gensouki: Spirit Chronicles | July 6, 2021 | — | 24 |
| Seiren | January 5, 2017 | — | 12 |
| Seishun Fūfu Monogatari: Koiko no Mainichi | September 22, 1989 | — | 2 |