| The PJs | January 10, 1999 | Fox Broadcasting Company | 48 |
| The Plastic Man Comedy/Adventure Show | September 22, 1979 | American Broadcasting Company | — |
| The Plucky Duck Show | September 19, 1992 | Fox Broadcasting Company, Fox Kids | 13 |
| The Porky Pig Show | September 20, 1964 | — | 26 |
| The Power Team | 1990 | USA Network | 55 |
| The Powerpuff Girls | November 18, 1998 | Cartoon Network | 78 |
| The Powerpuff Girls | April 4, 2016 | Cartoon Network | 119 |
| The Prince | — | Hulu | 12 |
| The Problem Solverz | April 4, 2011 | Cartoon Network | 26 |
| The Proud Family | September 15, 2001 | Disney Channel | 52 |
| The Proud Family: Louder and Prouder | February 23, 2022 | Disney+ | 29 |
| The Puppy's Further Adventures | September 25, 1982 | American Broadcasting Company | 21 |
| The Quick Draw McGraw Show | September 28, 1959 | Broadcast syndication | 35 |
| The Real Adventures of Jonny Quest | August 26, 1996 | Cartoon Network | 52 |
| The Real Ghostbusters | September 13, 1986 | American Broadcasting Company | 140 |
| The Reluctant Dragon & Mr. Toad Show | September 12, 1970 | American Broadcasting Company | 17 |
| The Ren & Stimpy Show | August 11, 1991 | Nickelodeon | 52 |
| The Replacements | July 28, 2006 | Disney Channel, Toon Disney, ABC Kids | 52 |
| The Richie Rich/Scooby-Doo Show | November 8, 1980 | American Broadcasting Company | 21 |
| The Road Runner Show | September 10, 1966 | — | 48 |
| The Robonic Stooges | September 10, 1977 | CBS | 32 |
| The Rocketeer | November 8, 2019 | Disney Channel, Disney Jr. | 22 |
| The Rocky and Bullwinkle Show | November 19, 1959 | American Broadcasting Company | 163 |
| The Roman Holidays | September 9, 1972 | NBC | 13 |
| The Rotten Fruit | — | — | — |
| The Ruff & Reddy Show | December 14, 1957 | NBC | 50 |
| The Savage Dragon | September 21, 1995 | USA Network | 26 |
| The Scooby & Scrappy-Doo/Puppy Hour | September 25, 1982 | American Broadcasting Company | 13 |
| The Scooby-Doo Show | September 11, 1976 | American Broadcasting Company | 40 |
| The Scooby-Doo/Dynomutt Hour | September 11, 1976 | American Broadcasting Company | 16 |
| The Second Best Hospital in the Galaxy | February 23, 2024 | Amazon Prime Video | — |
| The Secret Files of the Spy Dogs | 1998 | Fox Broadcasting Company | 22 |
| The Secret Saturdays | October 3, 2008 | Cartoon Network | 36 |
| The Sensibles | — | — | 12 |
| The Shivering Truth | — | Adult Swim | — |
| The Shnookums and Meat Funny Cartoon Show | January 2, 1995 | Broadcast syndication | 13 |
| The Simpsons | December 17, 1989 | Fox Broadcasting Company | 814 |
| The Smokey Bear Show | September 6, 1969 | American Broadcasting Company | 17 |
| The Smurfs | September 12, 1981 | NBC | 256 |
| The Space Kidettes | September 10, 1966 | NBC | 20 |
| The Spectacular Spider-Man | March 8, 2008 | The CW | 26 |
| The Spooktacular New Adventures of Casper | February 24, 1996 | Fox Kids | 52 |
| The Stinky & Dirty Show | January 15, 2015 | Amazon Prime Video | 39 |
| The Story Keepers | 1995 | — | 13 |
| The Super Hero Squad Show | September 14, 2009 | Cartoon Network | 52 |
| The Super Mario Bros. Super Show! | September 4, 1989 | CBS | 52 |
| The Super Powers Team: Galactic Guardians | September 7, 1985 | American Broadcasting Company | 10 |
| The Sylvester & Tweety Mysteries | September 9, 1995 | The WB, Kids' WB | 52 |
| The Tex Avery Show | January 10, 1999 | Cartoon Network | 99 |
| The Three Musketeers | September 7, 1968 | NBC | 18 |
| The Tick | September 10, 1994 | Fox Broadcasting Company, Fox Kids | 36 |
| The Tiny Chef Show | September 9, 2022 | Nickelodeon | — |
| The Tom & Jerry Show | September 6, 1975 | American Broadcasting Company | 16 |
| The Tom and Jerry Comedy Show | September 6, 1980 | CBS | 15 |
| The Tom and Jerry Show | April 9, 2014 | Cartoon Network | 117 |
| The Tomfoolery Show | — | — | — |
| The Transformers | September 17, 1984 | Broadcast syndication | 98 |
| The Twisted Tales of Felix the Cat | September 16, 1995 | CBS | 21 |
| The Twisted Whiskers Show | October 10, 2010 | Discovery Family | 26 |
| The Venture Bros. | February 16, 2003 | Adult Swim, Cartoon Network | 81 |