| Xiaolin Showdown | November 1, 2003 | The WB, Kids' WB | 52 |
| Xyber 9: New Dawn | September 25, 1999 | Fox Kids | 22 |
| Yakkity Yak | November 9, 2003 | Cartoon Network | 52 |
| Yakky Doodle | 1960 | — | 32 |
| Yasuke | April 29, 2021 | — | 6 |
| Yin Yang Yo! | August 26, 2006 | Jetix | 65 |
| Yippee, Yappee and Yahooey | September 16, 1964 | — | 23 |
| Yo Yogi! | September 14, 1991 | NBC | 19 |
| Yogi Bear & Friends | 1967 | Broadcast syndication | 96 |
| Yogi's Gang | September 8, 1973 | American Broadcasting Company | 17 |
| Yogi's Space Race | September 9, 1978 | NBC | 13 |
| Yogi's Treasure Hunt | September 6, 1985 | Broadcast syndication | 27 |
| YOLO: Crystal Fantasy | March 31, 2020 | Adult Swim, Cartoon Network | — |
| Young Justice | November 26, 2010 | Cartoon Network | 98 |
| Young Robin Hood | September 15, 1991 | Broadcast syndication | 26 |
| Your Friendly Neighborhood Spider-Man | January 29, 2025 | Disney+ | 10 |
| Zack & Quack | February 7, 2014 | Nick Jr. Channel | 33 |
| Zafari | January 6, 2018 | — | 52 |
| Zak Storm | 2016 | Canal J | 39 |
| Zazoo U | September 8, 1990 | Fox Broadcasting Company | 13 |
| Zevo-3 | October 11, 2010 | Nicktoons | 26 |
| Zokie of Planet Ruby | December 31, 2023 | Amazon Prime Video | 26 |
| Zombie College | 2000 | — | 12 |
| Zombies: Addison's Moonstone Mystery | October 16, 2020 | Disney Channel | 14 |
| ZOMBIES: The Re-Animated Series | June 28, 2024 | Disney Channel | 30 |
| ZooPhobia | — | — | 1 |
| Zootopia+ | November 9, 2022 | Disney Channel, Disney+ | 6 |
| Zorro: Generation Z | March 16, 2006 | Telemundo, YTV | 26 |
| ¡Mucha Lucha! | August 17, 2002 | The WB, Kids' WB | 52 |
| Æon Flux | September 1, 1991 | MTV | 16 |