| Smarty Pants | August 29, 2022 | Canal+ Kids | 52 |
| Smeshariki. Azbuki | — | — | — |
| Smile Down the Runway | January 11, 2020 | — | 12 |
| Smile of the Arsnotoria the Animation | July 6, 2022 | — | 12 |
| Smile PreCure! | February 5, 2012 | — | 48 |
| Smiling Friends | January 10, 2022 | Adult Swim | 27 |
| Smoking Behind the Supermarket with You | July 10, 2026 | — | 12 |
| Smuggler | — | — | — |
| Snack Basue | January 13, 2024 | — | 13 |
| Snooper and Blabber | September 19, 1959 | — | 45 |
| Snorks | September 15, 1984 | NBC | 68 |
| Snow White with the Red Hair | July 6, 2015 | — | 24 |
| Snowball Earth | April 3, 2026 | — | 13 |
| So I'm a Spider, So What? | January 8, 2021 | — | 24 |
| So What's Wrong with Getting Reborn as a Goblin? | October 5, 2026 | — | — |
| So, I Can't Play H? | July 6, 2012 | — | 12 |
| Soar High! Isami | April 8, 1995 | NHK Educational TV | 50 |
| Soara and the House of Monsters | 2027 | — | — |
| Soaring Sky! Pretty Cure | February 5, 2023 | TV Asahi | 50 |
| Sobakasu Pucchi | March 31, 1969 | Fuji Television | — |
| Soccer Fever | April 4, 1994 | NHK Satellite 2 Television | 51 |
| Society of Virtue | 2017 | — | — |
| Sofia the First | November 18, 2012 | Disney Channel, Disney Jr. | 109 |
| Softenni | April 8, 2011 | Tokyo MX | 12 |
| Sola | April 7, 2007 | — | 13 |
| Solar Opposites | 2020 | Hulu | 63 |
| Solo Camping for Two | July 11, 2025 | — | 24 |
| Solo Leveling | January 7, 2024 | — | 25 |
| Solty Rei | October 6, 2005 | TV Asahi | 24 |
| Somali and the Forest Spirit | January 9, 2020 | — | 12 |
| Someday's Dreamers | January 9, 2003 | — | 12 |
| Someday's Dreamers II: Sora | July 3, 2008 | — | 12 |
| Something Else | 2002 | — | 26 |
| Sometimes Even Reality Is a Lie! | 2027 | — | — |
| SoniAni: Super Sonico the Animation | January 6, 2014 | AT-X | 12 |
| Sonic Boom | November 8, 2014 | Boomerang, Cartoon Network | 104 |
| Sonic Prime | December 15, 2022 | Netflix | 23 |
| Sonic Soldier Borgman | April 13, 1988 | — | 35 |
| Sonic the Hedgehog | September 18, 1993 | American Broadcasting Company | 26 |
| Sonic Underground | September 9, 1998 | TF1 | 40 |
| Sonic X | April 6, 2003 | TV Tokyo | 78 |
| Sonny Boy | July 15, 2021 | — | 12 |
| Sono Toki, Kanojo wa. | October 7, 2018 | — | — |
| Sons of Butcher | August 5, 2005 | Télétoon | 26 |
| Sophie & Virginie | December 12, 1990 | TF1 | 52 |
| Sophie La Girafe | — | — | 15 |
| Sora no Manimani | July 7, 2009 | AT-X | 12 |
| Sora o Miageru Shōjo no Hitomi ni Utsuru Sekai | January 14, 2009 | — | 9 |
| Sorairo Utility | January 4, 2025 | — | 12 |
| Sorcerer Hunters | October 3, 1995 | TV Tokyo | 26 |
| Sorcerer Hunters OVA | December 21, 1996 | — | 3 |
| Sorcerous Stabber Orphen | October 3, 1998 | TBS Television | 47 |
| Sorcerous Stabber Orphen | January 7, 2020 | — | 48 |
| Soreike! Zukkoke San'ningumi | April 4, 2004 | TV Tokyo | 26 |
| SOS Fairy Manu | — | — | 65 |
| Soul Buster | October 4, 2016 | — | 12 |
| Soul Eater | April 7, 2008 | Toku | 51 |
| Soul Eater Not! | April 8, 2014 | — | 12 |
| Soul Frame LAZENCA | November 3, 1997 | Munhwa Broadcasting Corporation | — |
| Soul Hunter | July 3, 1999 | TV Tokyo | 26 |