| Soul Land | — | Tencent Video | — |
| Soul Link | April 11, 2006 | — | 12 |
| Soul Quest Overdrive | May 24, 2011 | Adult Swim | 4 |
| Soulmate Adventure | April 1, 2017 | — | 26 |
| Sound of the Sky | January 4, 2010 | TV Tokyo | 12 |
| Sound! Euphonium | April 8, 2015 | — | 26 |
| Soupe Opéra | 1991 | France 3 | 26 |
| South Park | August 13, 1997 | Comedy Central, Paramount Comedy, Canal+ Polska | 344 |
| Space Ace | May 8, 1965 | Fuji Television | 52 |
| Space Angel | — | — | — |
| Space Battleship Tiramisu | April 3, 2018 | — | 26 |
| Space Battleship Yamato | October 6, 1974 | Yomiuri Telecasting Corporation | 26 |
| Space Battleship Yamato 2202: Warriors of Love | October 6, 2018 | — | — |
| Space Battleship Yamato II | October 14, 1978 | Yomiuri Telecasting Corporation | 26 |
| Space Battleship Yamato III | October 11, 1980 | Yomiuri Telecasting Corporation | 25 |
| Space Boy Soran | May 4, 1965 | — | 96 |
| Space Brothers | March 31, 2012 | — | 99 |
| Space Carrier Blue Noah | October 13, 1979 | — | 24 |
| Space Cats | September 14, 1991 | NBC | 13 |
| Space Chickens in Space | September 30, 2018 | Nine Network | 52 |
| Space Cobra | October 7, 1982 | — | 31 |
| Space Cops | — | Seoul Broadcasting System | 52 |
| Space Dandy | January 4, 2014 | — | 26 |
| Space Dongui-bogam | — | KBS 2TV, SBS TV | — |
| Space Emperor God Sigma | March 19, 1980 | — | 50 |
| Space Ghost | September 10, 1966 | CBS | 42 |
| Space Ghost Coast to Coast | September 23, 1994 | Adult Swim, Cartoon Network | 113 |
| Space Goofs | September 6, 1997 | France 3 | 104 |
| Space Nova | April 2, 2021 | — | — |
| Space Patrol Luluco | April 1, 2016 | Tokyo MX, AT-X, Nippon BS Broadcasting | 13 |
| Space Pirate Captain Harlock | March 14, 1978 | TV Asahi | 42 |
| Space Pirate Mito | January 5, 1999 | — | — |
| Space Runaway Ideon | May 8, 1980 | — | 39 |
| Space Sentinels | September 10, 1977 | NBC | 13 |
| Space Stars | September 12, 1981 | NBC | 11 |
| Space Strikers | September 10, 1995 | M6 | 26 |
| Space Symphony Maetel | August 5, 2004 | — | 15 |
| Space Warrior Baldios | June 30, 1980 | TV Tokyo | 31 |
| Spaceballs: The Animated Series | June 4, 2008 | Super Channel | 13 |
| Spaced Out | October 4, 2002 | Toon Disney, France 3 | 26 |
| Spare Me, Great Lord! | — | — | 24 |
| Sparks of Tomorrow | July 5, 2026 | — | 13 |
| Sparrow's Hotel | April 9, 2013 | — | 12 |
| Spartakus and the Sun Beneath the Sea | September 17, 1985 | France 2 | 52 |
| Special A | April 6, 2008 | Chiba Television Broadcasting | 24 |
| Special Agent Oso | April 4, 2009 | Disney Channel | 60 |
| Special Agent Oso: Three Healthy Steps | February 14, 2011 | Disney Jr. | — |
| Special Armored Battalion Dorvack | October 7, 1983 | — | 36 |
| Special Crime Investigation Unit Special 7 | October 6, 2019 | — | 12 |
| Special Kid Factory | — | — | — |
| Speed Buggy | September 8, 1973 | CBS | 16 |
| Speed Grapher | April 7, 2005 | TV Asahi | 24 |
| Speed Racer | April 2, 1967 | Fuji Television | 52 |
| Speed Racer: The Next Generation | May 2, 2008 | Nicktoons | 52 |
| Spheres | — | Munhwa Broadcasting Corporation | 26 |
| Spice and Wolf | January 2008 | — | 26 |
| Spice and Wolf: Merchant Meets the Wise Wolf | April 2, 2024 | — | 25 |
| Spicy City | July 11, 1997 | HBO | 6 |
| Spider Riders | March 25, 2006 | Kids' WB | 52 |
| Spider-Man | November 19, 1994 | Fox Broadcasting Company, Fox Kids | 65 |