| Silkroad Kids Yuto | September 16, 2006 | NHK Satellite 2 Television | 26 |
| Silver Fang | April 7, 1986 | TV Asahi | 21 |
| Silver Spoon | July 12, 2013 | — | 22 |
| Silver Surfer | February 7, 1998 | Fox Broadcasting Company | 13 |
| SilverHawks | September 8, 1986 | Broadcast syndication | 65 |
| Simba the King Lion | 1995 | — | 52 |
| Simon | December 17, 2016 | France 5 | 78 |
| Simon's Cat | 2008 | — | 151 |
| Simoun | April 3, 2006 | — | 26 |
| SimsalaGrimm | November 1, 1999 | KiKA | 52 |
| Sin cara 2.0 | September 27, 1991 | — | 2 |
| Sinbad Jr. and His Magic Belt | 1965 | Broadcast syndication | 102 |
| Since the Red Moon Appeared | — | — | — |
| Sing "Yesterday" for Me | April 4, 2020 | — | 12 |
| Sing, sing, sing! Children's song world | — | — | — |
| Sirius the Jaeger | July 12, 2018 | AT-X | 12 |
| Sirotan | October 3, 2026 | — | — |
| Sissi: The Young Empress | 2015 | — | 65 |
| Sister Princess | April 4, 2001 | — | 26 |
| Sister Princess RePure | April 4, 2001 | — | — |
| Sisters of Wellber | April 3, 2007 | — | 26 |
| Sit Down, Shut Up | April 19, 2009 | Fox Broadcasting Company | 13 |
| Sitting Ducks | September 13, 2001 | Cartoon Network | 26 |
| SK8 the Infinity | January 10, 2021 | — | 12 |
| Skate-Leading Stars | January 10, 2021 | — | 12 |
| Skazochnaya Rus | — | 1+1 | 182 |
| Skeleton Knight in Another World | April 7, 2022 | — | 12 |
| Skeleton Warriors | March 23, 1995 | CBS | 13 |
| Sket Dance | April 7, 2011 | TV Tokyo | 77 |
| Sketchbook ~full color's~ | October 2, 2007 | TV Tokyo | 13 |
| Skip and Loafer | April 4, 2023 | NHK General TV | 12 |
| Skip Beat! | October 5, 2008 | — | 25 |
| Skipper & Skeeto | 2000 | DR1 | 26 |
| Skippy: Adventures in Bushtown | 1998 | Nine Network | 26 |
| Skirt no Naka wa Kedamono Deshita | July 3, 2017 | — | — |
| Skrotnisse och hans vänner | September 27, 1985 | SVT2 | 13 |
| Skull Island | — | — | 8 |
| Skull-face Bookseller Honda-san | October 8, 2018 | — | 12 |
| Skunk Fu! | September 22, 2007 | The CW, BBC Children's and Education | 52 |
| Sky Girls | — | — | — |
| Sky Girls | July 5, 2007 | Chiba Television Broadcasting | 26 |
| Sky Wizards Academy | July 8, 2015 | — | 12 |
| Skyers 5 | October 4, 1967 | — | 38 |
| Skyhawks | — | — | — |
| Skyland | November 26, 2005 | France 2, Cartoon Network | 26 |
| Skylanders Academy | October 28, 2016 | Netflix | 38 |
| Slacker Cats | August 13, 2007 | Freeform | 12 |
| Slam Dunk | October 16, 1993 | TV Asahi | 101 |
| Slap Up Party: Record of the Arad War | April 4, 2009 | — | 26 |
| Slash | — | — | — |
| Slay the Gods | July 31, 2024 | — | 15 |
| Slayers | April 7, 1995 | — | 104 |
| Slayers Excellent | October 25, 1998 | — | 3 |
| Slayers Special | July 25, 1996 | — | 3 |
| Sleepy Princess in the Demon Castle | October 6, 2020 | AT-X, TV Tokyo, BS TV Tokyo | 12 |
| Slippin' Jimmy | May 23, 2022 | AMC+ | 6 |
| Slow Loop | January 7, 2022 | — | 12 |
| Slow Start | January 7, 2018 | Tokyo MX | 12 |
| Slow Step | June 1, 1991 | — | 5 |
| Slugterra | September 3, 2012 | WildBrainTV | 50 |