| Spider-Man | September 12, 1981 | Broadcast syndication | 26 |
| Spider-Man | September 9, 1967 | American Broadcasting Company | 52 |
| Spider-Man and His Amazing Friends | September 12, 1981 | NBC | 24 |
| Spider-Man Unlimited | October 2, 1999 | Fox Kids | 13 |
| Spider-Man: The New Animated Series | July 11, 2003 | MTV | 13 |
| Spider-Woman | September 22, 1979 | American Broadcasting Company | 16 |
| Spidey and His Amazing Friends | August 6, 2021 | Disney Jr. | 64 |
| Spiff and Hercules | 1989 | TF1 | 130 |
| Spike Team | November 21, 2010 | Rai 2 | 78 |
| Spiral Zone | September 21, 1987 | Broadcast syndication | 65 |
| Spiral: The Bonds of Reasoning | October 1, 2002 | TV Tokyo | 25 |
| Spirit Circle | — | — | — |
| Spirit of Wonder: Shōnen Kagaku Club | January 25, 2001 | — | 2 |
| Spirit Rangers | October 10, 2022 | Netflix | 10 |
| Spirit Riding Free | May 5, 2017 | Netflix | 52 |
| Spirit Riding Free: Pony Tales | August 9, 2019 | — | 10 |
| Spirit Warrior | — | — | — |
| Spiritpact | — | — | — |
| Spirou et Fantasio | — | M6 | 39 |
| Splash and Bubbles | November 23, 2016 | PBS, PBS Kids | 40 |
| Spliced | September 19, 2009 | Télétoon | 26 |
| Spocon! | September 26, 2014 | — | 2 |
| SpongeBob SquarePants | May 1, 1999 | Nickelodeon, ARB Günəş | 330 |
| SpongeBob SquarePants Presents The Tidal Zone | — | — | — |
| Spooky Wolf | March 13, 2024 | Rai Gulp, RaiPlay | 26 |
| Sports Cartoons | — | — | — |
| Spriggan | June 18, 2022 | Netflix | 6 |
| Sprookjesboom | — | RTL Telekids | 156 |
| Spy Classroom | January 5, 2023 | — | 12 |
| Spy Groove | July 13, 2000 | MTV | 13 |
| Spy × Family | April 9, 2022 | — | 50 |
| Squid Girl | October 5, 2010 | TV Tokyo | 24 |
| Squidbillies | October 16, 2005 | Adult Swim | 110 |
| Squiddly Diddly | October 2, 1965 | NBC | 26 |
| Squirrel Boy | May 27, 2006 | Cartoon Network | 52 |
| Squish | December 20, 2019 | — | — |
| SSS-Class Revival Hunter | January 2027 | — | — |
| SSSS.Dynazenon | April 2, 2021 | — | 12 |
| SSSS.Gridman | October 7, 2018 | — | 12 |
| St. Luminous Mission High School | October 5, 1998 | — | 13 |
| St. Michaela Gakuen Hyōryūki | June 22, 1990 | — | 2 |
| St. Michaela Gakuen Hyōryūki II | October 21, 1994 | — | 2 |
| Stackarsramsor | October 5, 1985 | SVT2 | — |
| Staines Down Drains | October 2006 | Seven Network, TVNZ 2 | 27 |
| STAND MY HEROES PIECE OF TRUTH | — | — | — |
| Stand My Heroes: Piece of Truth | October 7, 2019 | — | 12 |
| Stanley | September 15, 2001 | Playhouse Disney, Disney Jr., Starz | 65 |
| Star Blazers 2199 | April 7, 2013 | MBS | — |
| Star Detective Precure! | February 1, 2026 | — | — |
| Star Driver | October 3, 2010 | — | 25 |
| Star Key | — | — | — |
| Star Martial God Technique | January 28, 2021 | IQIYI, Mango TV | — |
| Star Ocean EX | April 3, 2001 | — | 26 |
| Star of the Giants | March 30, 1968 | — | — |
| Star Street: The Adventures of the Star Kids | 1989 | — | — |
| Star Trek: Lower Decks | August 6, 2020 | Paramount+ | 50 |
| Star Trek: Prodigy | October 28, 2021 | Netflix, Paramount+ | 40 |
| Star Trek: Scouts | — | — | — |
| Star Trek: The Animated Series | September 8, 1973 | NBC | 22 |
| Star Twinkle Precure | February 3, 2019 | — | 49 |