| Super Wish | June 4, 2022 | — | 26 |
| Super Yizai | — | Youman Cartoon Television | 52 |
| Super Yo-Yo | December 1, 1998 | — | 22 |
| Super Zach | — | — | — |
| Super Zugan | October 8, 1992 | Fuji Television | 21 |
| Superbook | October 9, 1981 | Christian Broadcasting Network | 52 |
| Superbook | September 1, 2011 | Christian Broadcasting Network | 52 |
| Superbuns | October 17, 2023 | Treehouse TV, Universal Kids, Peacock | — |
| Supercrooks | — | Netflix | 13 |
| Superdino | March 27, 2022 | SBS TV | 52 |
| Superhero Kindergarten | April 23, 2021 | — | 26 |
| Superior Defender Gundam Force | September 1, 2003 | — | — |
| Superjail! | May 13, 2007 | Adult Swim | 36 |
| SuperKitties | January 11, 2023 | Disney Jr. | 41 |
| Superman | September 17, 1988 | CBS | 13 |
| Superman: The Animated Series | September 6, 1996 | The WB, Kids' WB | 54 |
| SuperMansion | October 8, 2015 | — | 46 |
| Supermodels | June 14, 1999 | Antena 3 | — |
| Supernatural Academy | January 20, 2022 | Peacock | — |
| Supernatural: The Animation | February 23, 2011 | — | 22 |
| SuperNews! | August 19, 2005 | Current TV | 67 |
| Supernoobs | November 2, 2015 | Cartoon Network, Family Channel | 52 |
| Superstar Romy | — | MBC TV | 13 |
| SuperTed | October 4, 1983 | S4C | 36 |
| Superthings Rivals of Kaboom, Kazoom Power | September 9, 2024 | Clan | 52 |
| Supertrons | — | KBS 2TV, KBS 1TV | — |
| Suppose a Kid From the Last Dungeon Boonies Moved to a Starter Town | January 4, 2021 | — | 12 |
| Suraj: The Rising Star | — | — | 26 |
| Sushi and Beyond | April 12, 2015 | NHK General TV | 24 |
| Sushi Police | January 6, 2016 | — | — |
| Sushi Sumo | April 3, 2021 | — | 52 |
| Susie-chan to Marvy | April 5, 1999 | NHK Educational TV | 104 |
| Suteki! Sakura Mama | December 2, 2000 | BS Fuji | 18 |
| Suzakinishi the Animation | July 8, 2015 | — | 12 |
| Suzuka | July 7, 2005 | — | 26 |
| Swallowed Star | — | — | — |
| Swamp Thing | October 31, 1990 | Fox Broadcasting Company, USA Network, Fox Kids | 5 |
| SWAT Kats: The Radical Squadron | September 11, 1993 | TBS | 23 |
| Sweet Blue Flowers | July 2, 2009 | Fuji Television | 11 |
| Sweet Little Monsters | — | VTM Kids | 130 |
| Sweet Reincarnation | July 4, 2023 | — | 12 |
| Sweet Valerian | August 1, 2004 | — | 26 |
| Sweetness and Lightning | July 4, 2016 | — | 12 |
| Sword Art Online | July 7, 2012 | Tokyo MX | 96 |
| Sword Art Online Alternative Gun Gale Online | April 8, 2018 | — | 12 |
| Sword Gai: The Animation | March 23, 2018 | Netflix | — |
| Sword of Coming | August 15, 2024 | Tencent Video | 26 |
| Sword of the Demon Hunter: Kijin Gentōshō | March 31, 2025 | — | 24 |
| Sword Oratoria: Is It Wrong to Try to Pick Up Girls in a Dungeon? On the Side | April 14, 2017 | — | 12 |
| Sydney Sailboat | — | ABC Kids | 52 |
| Sylvan | — | TV3 | 91 |
| Sylvanian Families | September 18, 1987 | Broadcast syndication | 13 |
| Sylvanian Families | October 7, 2017 | TV Tokyo | — |
| Sym-Bionic Titan | September 17, 2010 | Cartoon Network | 20 |
| Symphogear | January 6, 2012 | — | 65 |
| Synduality: Noir | July 11, 2023 | — | 24 |
| Synostone | — | KBS 2TV, KBS 1TV | 52 |
| Sítio do Picapau Amarelo | January 7, 2012 | TV Globo | 52 |
| Sōten Kōro | April 8, 2009 | — | 26 |
| Sōya Monogatari | February 7, 1984 | — | 21 |