| Secret Millionaires Club | October 23, 2011 | Hub Network | 26 |
| Shadow Raiders | September 16, 1998 | YTV | 26 |
| Shanna's Show | June 20, 2004 | Playhouse Disney | 14 |
| Shaun the Sheep | March 5, 2007 | BBC One, BBC Children's and Education | 188 |
| She-Ra and the Princesses of Power | November 13, 2018 | Netflix | 52 |
| Sherlock Holmes in the 22nd Century | May 6, 1999 | Fox Kids | 26 |
| Sherlock Yack | May 4, 2011 | TF1 | 52 |
| SheZow | December 15, 2012 | Network 10 | 26 |
| Shimajirō Hesoka | April 5, 2010 | TV Setouchi | 202 |
| Shimajirō no Wow! | April 2, 2012 | TV Setouchi | — |
| Shimmer and Shine | August 24, 2015 | Nickelodeon, Nick Jr. Channel, TV Cultura | 86 |
| Shining Star | October 16, 2017 | MBC TV | — |
| Shuriken School | February 11, 2006 | CITV | 26 |
| Sid the Science Kid | September 1, 2008 | PBS, PBS Kids | 54 |
| Sidekick | September 3, 2010 | YTV | 52 |
| Simon | December 17, 2016 | France 5 | 78 |
| Skippy: Adventures in Bushtown | 1998 | Nine Network | 26 |
| Skrotnisse och hans vänner | September 27, 1985 | SVT2 | 13 |
| Skunk Fu! | September 22, 2007 | The CW, BBC Children's and Education | 52 |
| Slugterra | September 3, 2012 | WildBrainTV | 50 |
| Sonic Prime | December 15, 2022 | Netflix | 23 |
| Sonic the Hedgehog | September 18, 1993 | American Broadcasting Company | 26 |
| Sophie & Virginie | December 12, 1990 | TF1 | 52 |
| Sophie La Girafe | — | — | 15 |
| SOS Fairy Manu | — | — | 65 |
| Soupe Opéra | 1991 | France 3 | 26 |
| Space Cats | September 14, 1991 | NBC | 13 |
| Space Sentinels | September 10, 1977 | NBC | 13 |
| Spaced Out | October 4, 2002 | Toon Disney, France 3 | 26 |
| Speed Racer: The Next Generation | May 2, 2008 | Nicktoons | 52 |
| Spider-Man | November 19, 1994 | Fox Broadcasting Company, Fox Kids | 65 |
| Spidey and His Amazing Friends | August 6, 2021 | Disney Jr. | 64 |
| Splash and Bubbles | November 23, 2016 | PBS, PBS Kids | 40 |
| SpongeBob SquarePants Presents The Tidal Zone | — | — | — |
| Sprookjesboom | — | RTL Telekids | 156 |
| Star Trek: Prodigy | October 28, 2021 | Netflix, Paramount+ | 40 |
| Star Trek: Scouts | — | — | — |
| Star Trek: The Animated Series | September 8, 1973 | NBC | 22 |
| Star vs. the Forces of Evil | January 18, 2015 | Disney Channel, Disney XD | 77 |
| Star Wars: Clone Wars | November 7, 2003 | Cartoon Network | 25 |
| Star Wars: Droids | September 7, 1985 | American Broadcasting Company | 13 |
| Star Wars: The Clone Wars | October 3, 2008 | Cartoon Network, Netflix, Disney+ | 133 |
| Star Wars: Young Jedi Adventures | May 4, 2023 | Disney Channel | 19 |
| Steven Universe | November 4, 2013 | Cartoon Network | 108 |
| Stillwater | December 4, 2020 | Apple TV | 40 |
| Strawberry Shortcake's Berry Bitty Adventures | October 10, 2010 | Hub Network | 65 |
| Strawberry Shortcake: Berry in the Big City | September 18, 2021 | Wildbrain Entertainment | 120 |
| Stuart Little | March 1, 2003 | HBO | 13 |
| Summer Memories | — | — | — |
| Sunny Day: Style of Girls | July 2026 | Nick Jr. | 1 |
| Super Duper Bunny League | April 19, 2025 | Nickelodeon | 25 |
| Super Mario World | September 14, 1991 | NBC | 13 |
| Super Monsters | October 13, 2017 | Netflix | 22 |
| Super President | September 16, 1967 | NBC | 30 |
| Super Why! | September 3, 2007 | PBS Kids, CBC Kids | 103 |
| Super Wings | September 1, 2014 | Korea Educational Broadcasting System, Carousel | 424 |
| Super Zach | — | — | — |
| Supernoobs | November 2, 2015 | Cartoon Network, Family Channel | 52 |
| SuperTed | October 4, 1983 | S4C | 36 |
| Superthings Rivals of Kaboom, Kazoom Power | September 9, 2024 | Clan | 52 |