| Sabrina's Secret Life | November 10, 2003 | Broadcast syndication | 26 |
| Sabrina: Secrets of a Teenage Witch | October 12, 2013 | Discovery Family | 26 |
| Sabrina: The Animated Series | September 6, 1999 | American Broadcasting Company, UPN | 65 |
| Sago Mini Friends | September 16, 2022 | — | — |
| Sagwa, the Chinese Siamese Cat | September 3, 2001 | Treehouse TV, PBS Kids | 40 |
| Samurai Jack | August 10, 2001 | Adult Swim, Cartoon Network | 62 |
| Samurai Rabbit: The Usagi Chronicles | April 28, 2022 | Netflix | — |
| Sanjay and Craig | May 25, 2013 | Nickelodeon | 45 |
| Santa Inc. | December 2, 2021 | HBO Max | — |
| Santiago of the Seas | October 9, 2020 | Nickelodeon | 58 |
| Santo Bugito | September 16, 1995 | CBS | 13 |
| Saturday Morning All Star Hits! | December 10, 2021 | — | — |
| Saturday Supercade | September 17, 1983 | CBS | 26 |
| Sausage Party: Foodtopia | July 11, 2024 | Amazon Prime Video | 16 |
| Scary Scooby Funnies | October 20, 1984 | American Broadcasting Company | — |
| Scavengers Reign | October 19, 2023 | HBO Max | 12 |
| Schoolhouse Rock! | January 6, 1973 | American Broadcasting Company | 64 |
| Scooby's All-Star Laff-A-Lympics | September 10, 1977 | American Broadcasting Company | 24 |
| Scooby's Mystery Funhouse | September 7, 1985 | American Broadcasting Company | 21 |
| Scooby-Doo and Guess Who? | June 27, 2019 | Cartoon Network | 26 |
| Scooby-Doo and Scrappy-Doo | September 22, 1979 | American Broadcasting Company | 16 |
| Scooby-Doo and Scrappy-Doo | November 8, 1980 | American Broadcasting Company | 33 |
| Scooby-Doo! Mystery Incorporated | April 5, 2010 | Cartoon Network | 52 |
| Scooby-Doo, Where Are You! | September 13, 1969 | CBS | 25 |
| Scott Pilgrim Takes Off | November 17, 2023 | Netflix | 8 |
| Scruffy | — | — | 3 |
| Sea Dogs: Adventures on the Seven Seas | — | — | — |
| Sealab 2020 | September 9, 1972 | NBC | 13 |
| Sealab 2021 | December 21, 2000 | Adult Swim | 52 |
| Secret Level | — | Amazon Prime Video | 15 |
| Secret Millionaires Club | October 23, 2011 | Hub Network | 26 |
| Secret Mountain Fort Awesome | August 1, 2011 | Cartoon Network | 26 |
| Secret Squirrel | 1965 | NBC, Cartoon Network | 39 |
| Sectaurs | — | — | — |
| Seth MacFarlane's Cavalcade of Cartoon Comedy | September 10, 2008 | YouTube | 50 |
| Shaggy & Scooby-Doo Get a Clue! | September 23, 2006 | The CW, Kids' WB | 26 |
| Shanna's Show | June 20, 2004 | Playhouse Disney | 14 |
| Shaq’s Garage | — | — | 52 |
| Sharkdog | September 3, 2021 | Netflix | — |
| Shazzan | September 9, 1967 | CBS | 36 |
| She-Ra and the Princesses of Power | November 13, 2018 | Netflix | 52 |
| She-Ra: Princess of Power | September 9, 1985 | Broadcast syndication | 93 |
| Sheep in the Big City | November 17, 2000 | Cartoon Network | 26 |
| Sheriff Callie's Wild West | December 13, 2013 | Disney Channel | 45 |
| Sherlock Holmes in the 22nd Century | May 6, 1999 | Fox Kids | 26 |
| Sherwood | March 6, 2019 | YouTube Premium | 10 |
| SheZow | December 15, 2012 | Network 10 | 26 |
| Shimmer and Shine | August 24, 2015 | Nickelodeon, Nick Jr. Channel, TV Cultura | 86 |
| Shirt Tales | September 18, 1982 | NBC | 23 |
| Shorties Watchin' Shorties | April 28, 2004 | Comedy Central | 13 |
| Sid the Science Kid | September 1, 2008 | PBS, PBS Kids | 54 |
| Siegfried & Roy: Masters of the Impossible | September 14, 1996 | Fox Kids | 4 |
| Silver Surfer | February 7, 1998 | Fox Broadcasting Company | 13 |
| SilverHawks | September 8, 1986 | Broadcast syndication | 65 |
| Sinbad Jr. and His Magic Belt | 1965 | Broadcast syndication | 102 |
| Sit Down, Shut Up | April 19, 2009 | Fox Broadcasting Company | 13 |
| Sitting Ducks | September 13, 2001 | Cartoon Network | 26 |
| Skeleton Warriors | March 23, 1995 | CBS | 13 |
| Skull Island | — | — | 8 |
| Skyhawks | — | — | — |