| Skylanders Academy | October 28, 2016 | Netflix | 38 |
| Slacker Cats | August 13, 2007 | Freeform | 12 |
| Slippin' Jimmy | May 23, 2022 | AMC+ | 6 |
| Smiling Friends | January 10, 2022 | Adult Swim | 27 |
| Snooper and Blabber | September 19, 1959 | — | 45 |
| Snorks | September 15, 1984 | NBC | 68 |
| Sofia the First | November 18, 2012 | Disney Channel, Disney Jr. | 109 |
| Solar Opposites | 2020 | Hulu | 63 |
| Sonic Boom | November 8, 2014 | Boomerang, Cartoon Network | 104 |
| Sonic Prime | December 15, 2022 | Netflix | 23 |
| Sonic the Hedgehog | September 18, 1993 | American Broadcasting Company | 26 |
| Soul Quest Overdrive | May 24, 2011 | Adult Swim | 4 |
| South Park | August 13, 1997 | Comedy Central, Paramount Comedy, Canal+ Polska | 344 |
| Space Angel | — | — | — |
| Space Cats | September 14, 1991 | NBC | 13 |
| Space Ghost | September 10, 1966 | CBS | 42 |
| Space Ghost Coast to Coast | September 23, 1994 | Adult Swim, Cartoon Network | 113 |
| Space Sentinels | September 10, 1977 | NBC | 13 |
| Space Stars | September 12, 1981 | NBC | 11 |
| Space Strikers | September 10, 1995 | M6 | 26 |
| Spaceballs: The Animated Series | June 4, 2008 | Super Channel | 13 |
| Special Agent Oso | April 4, 2009 | Disney Channel | 60 |
| Special Agent Oso: Three Healthy Steps | February 14, 2011 | Disney Jr. | — |
| Speed Buggy | September 8, 1973 | CBS | 16 |
| Speed Racer: The Next Generation | May 2, 2008 | Nicktoons | 52 |
| Spicy City | July 11, 1997 | HBO | 6 |
| Spider-Man | November 19, 1994 | Fox Broadcasting Company, Fox Kids | 65 |
| Spider-Man | September 12, 1981 | Broadcast syndication | 26 |
| Spider-Man | September 9, 1967 | American Broadcasting Company | 52 |
| Spider-Man and His Amazing Friends | September 12, 1981 | NBC | 24 |
| Spider-Man Unlimited | October 2, 1999 | Fox Kids | 13 |
| Spider-Man: The New Animated Series | July 11, 2003 | MTV | 13 |
| Spider-Woman | September 22, 1979 | American Broadcasting Company | 16 |
| Spidey and His Amazing Friends | August 6, 2021 | Disney Jr. | 64 |
| Spiral Zone | September 21, 1987 | Broadcast syndication | 65 |
| Spirit Rangers | October 10, 2022 | Netflix | 10 |
| Spirit Riding Free | May 5, 2017 | Netflix | 52 |
| Spirit Riding Free: Pony Tales | August 9, 2019 | — | 10 |
| Splash and Bubbles | November 23, 2016 | PBS, PBS Kids | 40 |
| SpongeBob SquarePants | May 1, 1999 | Nickelodeon, ARB Günəş | 330 |
| Spy Groove | July 13, 2000 | MTV | 13 |
| Squidbillies | October 16, 2005 | Adult Swim | 110 |
| Squiddly Diddly | October 2, 1965 | NBC | 26 |
| Squirrel Boy | May 27, 2006 | Cartoon Network | 52 |
| Stanley | September 15, 2001 | Playhouse Disney, Disney Jr., Starz | 65 |
| Star Street: The Adventures of the Star Kids | 1989 | — | — |
| Star Trek: Lower Decks | August 6, 2020 | Paramount+ | 50 |
| Star Trek: Prodigy | October 28, 2021 | Netflix, Paramount+ | 40 |
| Star Trek: The Animated Series | September 8, 1973 | NBC | 22 |
| Star vs. the Forces of Evil | January 18, 2015 | Disney Channel, Disney XD | 77 |
| Star Wars Detours | — | — | — |
| Star Wars Forces of Destiny | July 3, 2017 | Disney Channel | 32 |
| Star Wars Rebels | October 3, 2014 | Disney XD | 75 |
| Star Wars Resistance | October 7, 2018 | Disney XD | 40 |
| Star Wars Tales | October 26, 2022 | Disney+ | — |
| Star Wars: Clone Wars | November 7, 2003 | Cartoon Network | 25 |
| Star Wars: Droids | September 7, 1985 | American Broadcasting Company | 13 |
| Star Wars: Maul – Shadow Lord | April 6, 2026 | Disney+ | 10 |
| Star Wars: Tales of the Empire | May 4, 2024 | Disney+ | — |
| Star Wars: Tales of the Underworld | — | Disney+ | — |