| City of Ghosts | 2021 | — | 6 |
| Clarence | April 14, 2014 | Cartoon Network | 130 |
| Class of 3000 | November 3, 2006 | Cartoon Network | 28 |
| Classical Baby | 2005 | HBO | 5 |
| Clerks: The Animated Series | May 31, 2000 | American Broadcasting Company | 6 |
| Click & Clack's As the Wrench Turns | July 9, 2008 | PBS | 10 |
| Clifford the Big Red Dog | September 4, 2000 | PBS Kids | 65 |
| Clone High | November 2, 2002 | MTV, Cartoon Network, HBO Max | 33 |
| Close Enough | July 9, 2020 | HBO Max | 24 |
| Cloudy with a Chance of Meatballs: The Series | February 20, 2017 | Cartoon Network | 104 |
| Clue Club | August 14, 1976 | CBS | 16 |
| Clutch Cargo | March 9, 1959 | — | 52 |
| Coconut Fred's Fruit Salad Island | September 17, 2005 | Kids' WB | 13 |
| Code Monkeys | July 11, 2007 | G4 | 26 |
| Codename: Kids Next Door | December 6, 2002 | Cartoon Network | 78 |
| Comi and Bebe | — | EBS 1TV | — |
| Common Side Effects | February 2, 2025 | Adult Swim | 10 |
| Conan the Adventurer | September 12, 1992 | Broadcast syndication | 65 |
| Constantine: City of Demons | March 24, 2018 | CW Seed | 2 |
| Cool McCool | September 10, 1966 | NBC | 20 |
| Corduroy | September 30, 2000 | TVOKids | 26 |
| Cosmic Quantum Ray | 2009 | KiKA, Discovery Family, France 3 | 26 |
| Courage the Cowardly Dog | November 12, 1999 | Cartoon Network | 52 |
| Courageous Cat and Minute Mouse | 1960 | Broadcast syndication | 130 |
| Cow and Chicken | December 15, 1995 | Cartoon Network | 52 |
| Craig of the Creek | March 30, 2018 | Cartoon Network | 180 |
| Crashbox | February 1, 1999 | HBO | 52 |
| Creative Galaxy | April 19, 2013 | Amazon Prime Video | 36 |
| Creature Commandos | December 5, 2024 | HBO Max | 7 |
| Creepy Crawlers | October 4, 1994 | Channel 4, Italia 1, Canale 5, M6, The Children's Channel | 22 |
| Cro | September 18, 1993 | American Broadcasting Company | 20 |
| Crossing Swords | June 12, 2020 | Hulu | 20 |
| Crusader Rabbit | August 1, 1950 | Broadcast syndication | 455 |
| Curious George | September 4, 2006 | PBS Kids, Peacock | 198 |
| Curious George | — | — | — |
| Cyberchase | January 21, 2002 | Cartoon Network, CBC Television, TV Brasil, Band, TV Cultura, PBS Kids, PBS Kids Go! | 153 |
| D.I.C.E. | January 22, 2005 | — | 40 |
| Da Boom Crew | September 11, 2004 | — | 13 |
| Da Jammies | August 31, 2015 | Netflix | 13 |
| Daily Folks | — | — | 1 |
| Dan Vs. | January 1, 2011 | Discovery Family | 53 |
| Dang! | September 8, 2026 | Netflix | 8 |
| Danger & Eggs | June 30, 2017 | — | 13 |
| Daniel Spellbound | October 27, 2022 | Netflix | 10 |
| Daniel Tiger's Neighborhood | September 3, 2012 | CBC Television, PBS Kids | 139 |
| Danny Phantom | April 3, 2004 | Nicktoons, Nickelodeon | 53 |
| Daria | March 3, 1997 | MTV | 67 |
| Darkstalkers | September 30, 1995 | UPN | 13 |
| Darkwing Duck | September 7, 1991 | American Broadcasting Company, Disney Channel, Broadcast syndication | 91 |
| Dastardly and Muttley in Their Flying Machines | September 13, 1969 | CBS | 17 |
| Dave the Barbarian | January 23, 2004 | Disney Channel | 21 |
| Davey and Goliath | February 25, 1961 | Broadcast syndication | 72 |
| Davy Crockett | — | — | — |
| Dawn of the Croods | December 24, 2015 | Netflix | 52 |
| DC Nation Shorts | November 11, 2011 | Cartoon Network | 164 |
| DC Super Hero Girls | October 1, 2015 | YouTube | 112 |
| DC Super Hero Girls | March 8, 2019 | Cartoon Network | 78 |
| DC Super Hero Girls: Super Shorts | January 17, 2019 | YouTube | 52 |
| DC's World's Funnest | November 11, 2011 | Cartoon Network | 10 |
| Dead End: Paranormal Park | June 16, 2022 | Netflix | — |