| Sanxingdui Glory Awakening | — | Kaku Children's Television | 52 |
| Sarah & Duck | February 18, 2013 | CBeebies | 160 |
| Saturday Morning All Star Hits! | December 10, 2021 | — | — |
| Saturday Supercade | September 17, 1983 | CBS | 26 |
| SauceRia | — | KBS 2TV | 26 |
| Sauerkraut | December 6, 1992 | ZDF | 13 |
| Sausage Party: Foodtopia | July 11, 2024 | Amazon Prime Video | 16 |
| Sayed Android | June 6, 2016 | — | — |
| Scan2Go | August 9, 2010 | Seoul Broadcasting System | 52 |
| Scaredy Squirrel | April 1, 2011 | YTV | 52 |
| Scary Larry | — | — | 52 |
| Scary Scooby Funnies | October 20, 1984 | American Broadcasting Company | — |
| Scavengers Reign | October 19, 2023 | HBO Max | 12 |
| School for Vampires | August 26, 2006 | Das Erste | 104 |
| Schoolhouse Rock! | January 6, 1973 | American Broadcasting Company | 64 |
| Scissor Seven | April 25, 2018 | — | — |
| Scooby's All-Star Laff-A-Lympics | September 10, 1977 | American Broadcasting Company | 24 |
| Scooby's Mystery Funhouse | September 7, 1985 | American Broadcasting Company | 21 |
| Scooby-Doo and Guess Who? | June 27, 2019 | Cartoon Network | 26 |
| Scooby-Doo and Scrappy-Doo | September 22, 1979 | American Broadcasting Company | 16 |
| Scooby-Doo and Scrappy-Doo | November 8, 1980 | American Broadcasting Company | 33 |
| Scooby-Doo! Mystery Incorporated | April 5, 2010 | Cartoon Network | 52 |
| Scooby-Doo, Where Are You! | September 13, 1969 | CBS | 25 |
| Screechers Wild! | — | Nickelodeon, Carousel | — |
| Scruff | November 1, 2000 | 33 | 104 |
| Scruffy | — | — | 3 |
| Scumbag System | — | Tencent Video | — |
| Sea Dogs: Adventures on the Seven Seas | — | — | — |
| Sea Princesses | 2007 | Australian Broadcasting Corporation, Discovery Familia, Discovery Kids | 104 |
| Seabert | October 3, 1985 | Antenne 2 | 52 |
| Sealab 2020 | September 9, 1972 | NBC | 13 |
| Sealab 2021 | December 21, 2000 | Adult Swim | 52 |
| Sealook | — | KBS 1TV | 20 |
| Seaside Hotel | — | — | 26 |
| Season Elves | — | Kaku Children's Television | 52 |
| Secret Jouju: Bijou of Star | — | JEI TV | — |
| Secret Jouju: Guardians of Star | — | Tooniverse | 26 |
| Secret Jouju: Guardians of Star | — | JEI TV | 60 |
| Secret Level | — | Amazon Prime Video | 15 |
| Secret Millionaires Club | October 23, 2011 | Hub Network | 26 |
| Secret Mountain Fort Awesome | August 1, 2011 | Cartoon Network | 26 |
| Secret of the Cave | — | MBC 2 | 30 |
| Secret Squirrel | 1965 | NBC, Cartoon Network | 39 |
| Secrets of the Rivers | — | — | — |
| Sejong, the Great King | — | MBC TV | 5 |
| Semi and the Magic Cube | August 1, 2018 | EBS 1TV | 52 |
| Sendokai Champions | April 2, 2013 | Clan | 55 |
| Sergeant Stripes | September 1, 2003 | CBeebies | 26 |
| Seven States of Galaxy Saga | — | — | — |
| Shacolong from Animal Country | — | MBC TV | 30 |
| Shadow Raiders | September 16, 1998 | YTV | 26 |
| Shaggy & Scooby-Doo Get a Clue! | September 23, 2006 | The CW, Kids' WB | 26 |
| Shakespeare: The Animated Tales | November 9, 1992 | BBC Two, S4C | 12 |
| Shanna's Show | June 20, 2004 | Playhouse Disney | 14 |
| Shaolin Wuzang | December 13, 2006 | France 3 | 26 |
| Shape Island | January 20, 2023 | Apple TV | — |
| Shaq’s Garage | — | — | 52 |
| Sharkdog | September 3, 2021 | Netflix | — |
| Sharky & George | 1990 | Canal+, Canal Famille | 52 |
| Shasha & Milo | — | EBS 1TV | — |