| Shaun the Sheep | March 5, 2007 | BBC One, BBC Children's and Education | 188 |
| Shazzan | September 9, 1967 | CBS | 36 |
| She-Ra and the Princesses of Power | November 13, 2018 | Netflix | 52 |
| She-Ra: Princess of Power | September 9, 1985 | Broadcast syndication | 93 |
| Sheep in the Big City | November 17, 2000 | Cartoon Network | 26 |
| Sheriff Callie's Wild West | December 13, 2013 | Disney Channel | 45 |
| Sherlock Holmes in the 22nd Century | May 6, 1999 | Fox Kids | 26 |
| Sherlock Yack | May 4, 2011 | TF1 | 52 |
| Sherwood | March 6, 2019 | YouTube Premium | 10 |
| SheZow | December 15, 2012 | Network 10 | 26 |
| Shimmer and Shine | August 24, 2015 | Nickelodeon, Nick Jr. Channel, TV Cultura | 86 |
| Shining Girls | — | — | — |
| Shining Star | October 16, 2017 | MBC TV | — |
| Shining Star Korea | — | — | — |
| Shirt Tales | September 18, 1982 | NBC | 23 |
| Shiva | November 5, 2015 | Nickelodeon India | — |
| Shorties Watchin' Shorties | April 28, 2004 | Comedy Central | 13 |
| Shrouding the Heavens | — | — | — |
| Shuke and Beita | — | — | 13 |
| Shuriken School | February 11, 2006 | CITV | 26 |
| Sid the Science Kid | September 1, 2008 | PBS, PBS Kids | 54 |
| Sidekick | September 3, 2010 | YTV | 52 |
| Sidney | — | TV Rá-Tim-Bum | 26 |
| Siegfried & Roy: Masters of the Impossible | September 14, 1996 | Fox Kids | 4 |
| Silver Surfer | February 7, 1998 | Fox Broadcasting Company | 13 |
| SilverHawks | September 8, 1986 | Broadcast syndication | 65 |
| Simba the King Lion | 1995 | — | 52 |
| Simon | December 17, 2016 | France 5 | 78 |
| SimsalaGrimm | November 1, 1999 | KiKA | 52 |
| Sinbad Jr. and His Magic Belt | 1965 | Broadcast syndication | 102 |
| Sing, sing, sing! Children's song world | — | — | — |
| Sissi: The Young Empress | 2015 | — | 65 |
| Sit Down, Shut Up | April 19, 2009 | Fox Broadcasting Company | 13 |
| Sitting Ducks | September 13, 2001 | Cartoon Network | 26 |
| Skazochnaya Rus | — | 1+1 | 182 |
| Skeleton Warriors | March 23, 1995 | CBS | 13 |
| Skipper & Skeeto | 2000 | DR1 | 26 |
| Skippy: Adventures in Bushtown | 1998 | Nine Network | 26 |
| Skrotnisse och hans vänner | September 27, 1985 | SVT2 | 13 |
| Skull Island | — | — | 8 |
| Skunk Fu! | September 22, 2007 | The CW, BBC Children's and Education | 52 |
| Skyhawks | — | — | — |
| Skyland | November 26, 2005 | France 2, Cartoon Network | 26 |
| Skylanders Academy | October 28, 2016 | Netflix | 38 |
| Slacker Cats | August 13, 2007 | Freeform | 12 |
| Slash | — | — | — |
| Slippin' Jimmy | May 23, 2022 | AMC+ | 6 |
| Slugterra | September 3, 2012 | WildBrainTV | 50 |
| Smarty Pants | August 29, 2022 | Canal+ Kids | 52 |
| Smeshariki. Azbuki | — | — | — |
| Smiling Friends | January 10, 2022 | Adult Swim | 27 |
| Snooper and Blabber | September 19, 1959 | — | 45 |
| Snorks | September 15, 1984 | NBC | 68 |
| Sofia the First | November 18, 2012 | Disney Channel, Disney Jr. | 109 |
| Solar Opposites | 2020 | Hulu | 63 |
| Something Else | 2002 | — | 26 |
| Sonic Boom | November 8, 2014 | Boomerang, Cartoon Network | 104 |
| Sonic Prime | December 15, 2022 | Netflix | 23 |
| Sonic the Hedgehog | September 18, 1993 | American Broadcasting Company | 26 |
| Sonic Underground | September 9, 1998 | TF1 | 40 |