| Sons of Butcher | August 5, 2005 | Télétoon | 26 |
| Sophie & Virginie | December 12, 1990 | TF1 | 52 |
| Sophie La Girafe | — | — | 15 |
| SOS Fairy Manu | — | — | 65 |
| Soul Frame LAZENCA | November 3, 1997 | Munhwa Broadcasting Corporation | — |
| Soul Land | — | Tencent Video | — |
| Soul Quest Overdrive | May 24, 2011 | Adult Swim | 4 |
| Soupe Opéra | 1991 | France 3 | 26 |
| South Park | August 13, 1997 | Comedy Central, Paramount Comedy, Canal+ Polska | 344 |
| Space Angel | — | — | — |
| Space Cats | September 14, 1991 | NBC | 13 |
| Space Chickens in Space | September 30, 2018 | Nine Network | 52 |
| Space Cops | — | Seoul Broadcasting System | 52 |
| Space Dongui-bogam | — | KBS 2TV, SBS TV | — |
| Space Ghost | September 10, 1966 | CBS | 42 |
| Space Ghost Coast to Coast | September 23, 1994 | Adult Swim, Cartoon Network | 113 |
| Space Goofs | September 6, 1997 | France 3 | 104 |
| Space Nova | April 2, 2021 | — | — |
| Space Sentinels | September 10, 1977 | NBC | 13 |
| Space Strikers | September 10, 1995 | M6 | 26 |
| Spaceballs: The Animated Series | June 4, 2008 | Super Channel | 13 |
| Spaced Out | October 4, 2002 | Toon Disney, France 3 | 26 |
| Spare Me, Great Lord! | — | — | 24 |
| Spartakus and the Sun Beneath the Sea | September 17, 1985 | France 2 | 52 |
| Special Agent Oso | April 4, 2009 | Disney Channel | 60 |
| Special Agent Oso: Three Healthy Steps | February 14, 2011 | Disney Jr. | — |
| Speed Buggy | September 8, 1973 | CBS | 16 |
| Speed Racer: The Next Generation | May 2, 2008 | Nicktoons | 52 |
| Spheres | — | Munhwa Broadcasting Corporation | 26 |
| Spicy City | July 11, 1997 | HBO | 6 |
| Spider Riders | March 25, 2006 | Kids' WB | 52 |
| Spider-Man | November 19, 1994 | Fox Broadcasting Company, Fox Kids | 65 |
| Spider-Man | September 12, 1981 | Broadcast syndication | 26 |
| Spider-Man | September 9, 1967 | American Broadcasting Company | 52 |
| Spider-Man and His Amazing Friends | September 12, 1981 | NBC | 24 |
| Spider-Man Unlimited | October 2, 1999 | Fox Kids | 13 |
| Spider-Man: The New Animated Series | July 11, 2003 | MTV | 13 |
| Spider-Woman | September 22, 1979 | American Broadcasting Company | 16 |
| Spidey and His Amazing Friends | August 6, 2021 | Disney Jr. | 64 |
| Spiff and Hercules | 1989 | TF1 | 130 |
| Spike Team | November 21, 2010 | Rai 2 | 78 |
| Spiral Zone | September 21, 1987 | Broadcast syndication | 65 |
| Spirit Rangers | October 10, 2022 | Netflix | 10 |
| Spirit Riding Free | May 5, 2017 | Netflix | 52 |
| Spirit Riding Free: Pony Tales | August 9, 2019 | — | 10 |
| Spiritpact | — | — | — |
| Spirou et Fantasio | — | M6 | 39 |
| Splash and Bubbles | November 23, 2016 | PBS, PBS Kids | 40 |
| Spliced | September 19, 2009 | Télétoon | 26 |
| SpongeBob SquarePants | May 1, 1999 | Nickelodeon, ARB Günəş | 330 |
| SpongeBob SquarePants Presents The Tidal Zone | — | — | — |
| Spooky Wolf | March 13, 2024 | Rai Gulp, RaiPlay | 26 |
| Sports Cartoons | — | — | — |
| Sprookjesboom | — | RTL Telekids | 156 |
| Spy Groove | July 13, 2000 | MTV | 13 |
| Squidbillies | October 16, 2005 | Adult Swim | 110 |
| Squiddly Diddly | October 2, 1965 | NBC | 26 |
| Squirrel Boy | May 27, 2006 | Cartoon Network | 52 |
| Squish | December 20, 2019 | — | — |
| Stackarsramsor | October 5, 1985 | SVT2 | — |