| Soupe Opéra | 1991 | France 3 | 26 |
| South Park | August 13, 1997 | Comedy Central, Paramount Comedy, Canal+ Polska | 344 |
| Space Cats | September 14, 1991 | NBC | 13 |
| Space Chickens in Space | September 30, 2018 | Nine Network | 52 |
| Space Cops | — | Seoul Broadcasting System | 52 |
| Space Goofs | September 6, 1997 | France 3 | 104 |
| Spaceballs: The Animated Series | June 4, 2008 | Super Channel | 13 |
| Spaced Out | October 4, 2002 | Toon Disney, France 3 | 26 |
| Spartakus and the Sun Beneath the Sea | September 17, 1985 | France 2 | 52 |
| Special Agent Oso | April 4, 2009 | Disney Channel | 60 |
| Spheres | — | Munhwa Broadcasting Corporation | 26 |
| Spider-Woman | September 22, 1979 | American Broadcasting Company | 16 |
| Spiff and Hercules | 1989 | TF1 | 130 |
| Spirou et Fantasio | — | M6 | 39 |
| Splash and Bubbles | November 23, 2016 | PBS, PBS Kids | 40 |
| Spliced | September 19, 2009 | Télétoon | 26 |
| SpongeBob SquarePants | May 1, 1999 | Nickelodeon, ARB Günəş | 330 |
| Spooky Wolf | March 13, 2024 | Rai Gulp, RaiPlay | 26 |
| Sprookjesboom | — | RTL Telekids | 156 |
| Squidbillies | October 16, 2005 | Adult Swim | 110 |
| Staines Down Drains | October 2006 | Seven Network, TVNZ 2 | 27 |
| Star Trek: Lower Decks | August 6, 2020 | Paramount+ | 50 |
| Star Trek: Prodigy | October 28, 2021 | Netflix, Paramount+ | 40 |
| Star Trek: The Animated Series | September 8, 1973 | NBC | 22 |
| Star vs. the Forces of Evil | January 18, 2015 | Disney Channel, Disney XD | 77 |
| Star Wars Detours | — | — | — |
| Stargate Infinity | September 14, 2002 | Fox Broadcasting Company | 26 |
| Starveillance | January 5, 2007 | E! | 6 |
| Stitch & Ai | March 27, 2017 | CCTV-14 Children | 13 |
| Strawberry Shortcake | March 11, 2003 | CBS, Broadcast syndication | 22 |
| Stressed Eric | April 20, 1998 | BBC Two | 13 |
| Stretch Armstrong & The Flex Fighters | November 17, 2017 | Netflix | 13 |
| Strip Law | February 20, 2026 | — | — |
| Stripperella | June 26, 2003 | Spike TV, Paramount Network | 13 |
| Stroker and Hoop | August 1, 2004 | Adult Swim | 13 |
| Stuart Little | March 1, 2003 | HBO | 13 |
| Stunt Dawgs | September 28, 1992 | — | 40 |
| Submarine Jim | January 11, 2026 | France 4, RTS 2, RTS 1, Cartoon Network, CBBC, Cartoon Network, La Trois, ABC Entertains | 52 |
| Summer Camp Island | July 7, 2018 | Cartoon Network, HBO Max | 120 |
| Summer Memories | — | — | — |
| Sunny Bunnies | — | — | 124 |
| Sunny Day | August 21, 2017 | Treehouse TV | 60 |
| Sunny Girl No.23 | March 1, 2020 | Golden Eagle Cartoon | 52 |
| Super 4: Heroes United | August 1, 2014 | France 3 | 104 |
| Super Agent Jon Le Bon | December 18, 2020 | Canadian Broadcasting Corporation, ICI Radio-Canada Télé | 100 |
| Super Agent Jon le Bon! How to Become an Agent in 90 Seconds | — | TFO, ICI Radio-Canada Télé | 9 |
| Super Agent Jon le Bon! How to Save the World in 90 seconds | — | Canadian Broadcasting Corporation, TFO, ICI Radio-Canada Télé | 40 |
| Super Dave: Daredevil for Hire | September 12, 1992 | Fox Broadcasting Company | 13 |
| Super Drags | November 9, 2018 | Netflix | 5 |
| Super Duper Bunny League | April 19, 2025 | Nickelodeon | 25 |
| Super Mario World | September 14, 1991 | NBC | 13 |
| Super Monsters | October 13, 2017 | Netflix | 22 |
| Superbuns | October 17, 2023 | Treehouse TV, Universal Kids, Peacock | — |
| Superjail! | May 13, 2007 | Adult Swim | 36 |
| SuperNews! | August 19, 2005 | Current TV | 67 |
| Supernoobs | November 2, 2015 | Cartoon Network, Family Channel | 52 |
| Swamp Thing | October 31, 1990 | Fox Broadcasting Company, USA Network, Fox Kids | 5 |
| SWAT Kats: The Radical Squadron | September 11, 1993 | TBS | 23 |
| Sweet Little Monsters | — | VTM Kids | 130 |
| Sym-Bionic Titan | September 17, 2010 | Cartoon Network | 20 |