| S.O.S Fada Manu | — | Discovery Kids | — |
| S.O.S. Croco! | 1997 | TF1 | 65 |
| Saban's Adventures of Oliver Twist | February 1, 1996 | — | 52 |
| Saban's Around the World in Eighty Dreams | November 13, 1992 | Canal+ | 26 |
| Saber Rider and the Star Sheriffs | September 14, 1987 | Broadcast syndication | 52 |
| Sabrina: Secrets of a Teenage Witch | October 12, 2013 | Discovery Family | 26 |
| Sally the Witch 2 | October 9, 1989 | — | — |
| Sammy & Co | July 20, 2014 | — | 107 |
| Sanjay and Craig | May 25, 2013 | Nickelodeon | 45 |
| Santa Inc. | December 2, 2021 | HBO Max | — |
| Sanxingdui Glory Awakening | — | Kaku Children's Television | 52 |
| Sausage Party: Foodtopia | July 11, 2024 | Amazon Prime Video | 16 |
| Scaredy Squirrel | April 1, 2011 | YTV | 52 |
| School for Vampires | August 26, 2006 | Das Erste | 104 |
| Scooby's All-Star Laff-A-Lympics | September 10, 1977 | American Broadcasting Company | 24 |
| Scooby-Doo and Guess Who? | June 27, 2019 | Cartoon Network | 26 |
| Scooby-Doo and Scrappy-Doo | September 22, 1979 | American Broadcasting Company | 16 |
| Scooby-Doo, Where Are You! | September 13, 1969 | CBS | 25 |
| Sea Dogs: Adventures on the Seven Seas | — | — | — |
| Sea Princesses | 2007 | Australian Broadcasting Corporation, Discovery Familia, Discovery Kids | 104 |
| Seabert | October 3, 1985 | Antenne 2 | 52 |
| Sealook | — | KBS 1TV | 20 |
| Seaside Hotel | — | — | 26 |
| Secret Mountain Fort Awesome | August 1, 2011 | Cartoon Network | 26 |
| Secret Squirrel | 1965 | NBC, Cartoon Network | 39 |
| Sendokai Champions | April 2, 2013 | Clan | 55 |
| Sergeant Stripes | September 1, 2003 | CBeebies | 26 |
| Shaggy & Scooby-Doo Get a Clue! | September 23, 2006 | The CW, Kids' WB | 26 |
| Shaolin Wuzang | December 13, 2006 | France 3 | 26 |
| Sharkdog | September 3, 2021 | Netflix | — |
| Sharky & George | 1990 | Canal+, Canal Famille | 52 |
| Shaun the Sheep | March 5, 2007 | BBC One, BBC Children's and Education | 188 |
| She-Ra and the Princesses of Power | November 13, 2018 | Netflix | 52 |
| She-Ra: Princess of Power | September 9, 1985 | Broadcast syndication | 93 |
| Sheriff Callie's Wild West | December 13, 2013 | Disney Channel | 45 |
| Shorties Watchin' Shorties | April 28, 2004 | Comedy Central | 13 |
| Sidekick | September 3, 2010 | YTV | 52 |
| SilverHawks | September 8, 1986 | Broadcast syndication | 65 |
| Simba the King Lion | 1995 | — | 52 |
| Simon's Cat | 2008 | — | 151 |
| SimsalaGrimm | November 1, 1999 | KiKA | 52 |
| Sit Down, Shut Up | April 19, 2009 | Fox Broadcasting Company | 13 |
| Sitting Ducks | September 13, 2001 | Cartoon Network | 26 |
| Skazochnaya Rus | — | 1+1 | 182 |
| Skeleton Warriors | March 23, 1995 | CBS | 13 |
| Skipper & Skeeto | 2000 | DR1 | 26 |
| Skippy: Adventures in Bushtown | 1998 | Nine Network | 26 |
| Skrotnisse och hans vänner | September 27, 1985 | SVT2 | 13 |
| Skunk Fu! | September 22, 2007 | The CW, BBC Children's and Education | 52 |
| Skyland | November 26, 2005 | France 2, Cartoon Network | 26 |
| Slash | — | — | — |
| Slugterra | September 3, 2012 | WildBrainTV | 50 |
| Society of Virtue | 2017 | — | — |
| Sofia the First | November 18, 2012 | Disney Channel, Disney Jr. | 109 |
| Something Else | 2002 | — | 26 |
| Sonic Boom | November 8, 2014 | Boomerang, Cartoon Network | 104 |
| Sonic Prime | December 15, 2022 | Netflix | 23 |
| Sonic Underground | September 9, 1998 | TF1 | 40 |
| SOS Fairy Manu | — | — | 65 |
| Soul Quest Overdrive | May 24, 2011 | Adult Swim | 4 |